One-carbon (1-C) metabolic deficiency impairs homeostasis, driving disease development,
including infertility. It is of importance to summarize the current evidence regarding the …

Study question Does betaine and the active metabolite 5-MTHF influence cleavage
dynamics and expression of genes related to methylation during preimplantation embryos …

BACKGROUND Most reproductive failures originate during the periconceptional period and
are influenced by the age and the lifestyle of parents-to-be. We advance the hypothesis that …

Purpose To investigate impact of the one‐carbon metabolism (OCM) on oocyte maturity and
embryo development. Methods This prospective study analyzed 18 women who agreed to …

Balanced diet is the natural source of micronutrients, such as folate and vitamins, vital for
proper functioning of the body. One-carbon metabolic pathway along with folate and other …

Nutritional status and gene polymorphisms of one-carbon metabolism confer a well-known
interaction that in pregnant women may affect embryo viability and the health of the …

During development, a fetus and its placenta must respond to a changing maternal
environment to ensure normal growth is achieved and survival is maintained. The …

Background: This review discusses epigenetic mechanisms and the relationship of infertility
in men and women in relation to parameters pertaining to nutrition. Methods: A review of the …

Initially perceived simply as an ATP producer, mitochondria also participate in a wide range
of other cellular functions. Mitochondrial communication with the nucleus, as well as …

Infertility affects approximately 15–20% of individuals of reproductive age worldwide. Over
the last 40 years, assisted reproductive technology (ART) has helped millions of childless …