Berberine (BBR) is a natural isoquinoline alkaloid with very impressive health benefits. It is
one of the most effective natural supplements available; however, its ameliorative …

Hepatotoxicity is one of the major side effects of methotrexate (MTX), which restricts the
clinical use of this drug. Berberine (BBR) is a natural compound with multiple …

Berberine (BBR) is an isoquinoline alkaloid, reported to have multiple pharmacological
functions. However, its effects against CCl4‑induced oxidative damage remain poorly …

Berberine (BBR) is an isoquinoline alkaloid extracted from the roots, rhizomes and stems of
coptis. Liver fibrosis is a worldwide health problem with no established therapy until now …

Acetaminophen (APAP) hepatotoxicity remains the leading cause of drug-induced liver
injury due to the lack of safe and effective therapeutic agents. Berberine (BBR) is a natural …

Berberine (BBR) has been suggested to be a hepatoprotective agent for oxidative‐stress‐
related liver diseases because of its antioxidant activity. However, the antioxidant …

Aims We investigated the protective effect of berberine (BBR) on chronic liver fibrosis in mice
and the potential mechanism underlying the activation of AMP-activated protein kinase …

Methotrexate (MTX) is an efficient chemotherapeutic and immunosuppressant drug, but the
hepatotoxicity of MTX limits its clinical use. Naringin (Nar) is a flavonoid derived from Citrus …

The present study investigated the effects of berberine (BBR) on hepatic oxidative stress and
the nuclear factor erythroid 2‑related factor 2/antioxidant response element (Nrf2/ARE) …

Acute liver failure (ALF) is characterized by sudden large area of inflammation and extensive
hepatocyte apoptosis. This study identified the natural product berberine as a potential …