Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation
N Kubo, H Ishii, X Xiong, S Bianco… - Nature structural & …, 2021 - nature.com
The CCCTC-binding factor (CTCF) works together with the cohesin complex to drive the
formation of chromatin loops and topologically associating domains, but its role in gene …
formation of chromatin loops and topologically associating domains, but its role in gene …
Genome-wide studies of CCCTC-binding factor (CTCF) and cohesin provide insight into chromatin structure and regulation
Eukaryotic genomes are organized into higher order chromatin architectures by protein-
mediated long-range interactions in the nucleus. CCCTC-binding factor (CTCF), a sequence …
mediated long-range interactions in the nucleus. CCCTC-binding factor (CTCF), a sequence …
[HTML][HTML] CTCF and cohesin: linking gene regulatory elements with their targets
M Merkenschlager, DT Odom - Cell, 2013 - cell.com
Current epigenomics approaches have facilitated the genome-wide identification of
regulatory elements based on chromatin features and transcriptional regulator binding and …
regulatory elements based on chromatin features and transcriptional regulator binding and …
Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1
It remains unclear why acute depletion of CTCF (CCCTC-binding factor) and cohesin only
marginally affects expression of most genes despite substantially perturbing three …
marginally affects expression of most genes despite substantially perturbing three …
CTCF-mediated enhancer-promoter interaction is a critical regulator of cell-to-cell variation of gene expression
Recent studies indicate that even a homogeneous population of cells display heterogeneity
in gene expression and response to environmental stimuli. Although promoter structure …
in gene expression and response to environmental stimuli. Although promoter structure …
Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes
NJ Rinzema, K Sofiadis, SJD Tjalsma… - Nature Structural & …, 2022 - nature.com
Developmental gene expression is often controlled by distal regulatory DNA elements called
enhancers. Distant enhancer action is restricted to structural chromosomal domains that are …
enhancers. Distant enhancer action is restricted to structural chromosomal domains that are …
CTCF mediates chromatin looping via N-terminal domain-dependent cohesin retention
EM Pugacheva, N Kubo, D Loukinov… - Proceedings of the …, 2020 - National Acad Sciences
The DNA-binding protein CCCTC-binding factor (CTCF) and the cohesin complex function
together to shape chromatin architecture in mammalian cells, but the molecular details of …
together to shape chromatin architecture in mammalian cells, but the molecular details of …
CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression
M Franke, E De la Calle-Mustienes, A Neto… - Nature …, 2021 - nature.com
Coordinated chromatin interactions between enhancers and promoters are critical for gene
regulation. The architectural protein CTCF mediates chromatin looping and is enriched at …
regulation. The architectural protein CTCF mediates chromatin looping and is enriched at …
[HTML][HTML] Interplay between CTCF boundaries and a super enhancer controls cohesin extrusion trajectories and gene expression
To understand how chromatin domains coordinate gene expression, we dissected select
genetic elements organizing topology and transcription around the Prdm14 super enhancer …
genetic elements organizing topology and transcription around the Prdm14 super enhancer …
[HTML][HTML] CTCF binding polarity determines chromatin looping
E de Wit, ESM Vos, SJB Holwerda, C Valdes-Quezada… - Molecular cell, 2015 - cell.com
CCCTC-binding factor (CTCF) is an architectural protein involved in the three-dimensional
(3D) organization of chromatin. In this study, we assayed the 3D genomic contact profiles of …
(3D) organization of chromatin. In this study, we assayed the 3D genomic contact profiles of …