Ventilation and cerebral blood flow (CBF) are both sensitive to hypoxia and hypercapnia. To
compare chemosensitivity in these two systems, we made simultaneous measurements of …

This study investigated the changes in cerebral near-infrared spectroscopy (NIRS) signals,
cerebrovascular and ventilatory responses to hypoxia and CO2 during altitude exposure. At …

Cerebral blood flow is known to increase in response to hypoxia and to decrease with
hypocapnia. It is not known, however, whether these responses are altered in high‐altitude …

An altered acid–base balance following ascent to high altitude has been well established.
Such changes in pH buffering could potentially account for the observed increase in …

The effects of discontinuous hypoxia on cerebrovascular regulation in humans are unknown.
We hypothesized that five nocturnal hypoxic exposures (8 h/day) at a simulated altitude of …

Ascent to high-altitude elicits compensatory physiological adaptations in order to improve
oxygenation throughout the body. The brain is particularly vulnerable to the hypoxemia of …

Previous studies reported enhanced cerebrovascular CO2 reactivity upon ascent to high
altitude using linear models. However, there is evidence that this response may be …

The interindividual variation in ventilatory acclimatization to high altitude is likely reflected in
variability in the cerebrovascular responses to high altitude, particularly between brain …

During acclimatization to the hypoxia of altitude, the cerebral circulation is exposed to
arterial hypoxia and hypocapnia, two stimuli with opposing influences on cerebral blood flow …

The major challenge of going to altitude is related to the hypoxic environment; and of all the
acute compensatory responses to hypobaric hypoxia at altitude, hyperventilation is usually …