Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk
KA Perzel Mandell, NJ Eagles, R Wilton… - Nature …, 2021 - nature.com
DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of
gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed …
gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed …
An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation
Background Schizophrenia is a highly heritable, neuropsychiatric disorder characterized by
episodic psychosis and altered cognitive function. Despite success in identifying genetic …
episodic psychosis and altered cognitive function. Despite success in identifying genetic …
Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions
J Viana, E Hannon, E Dempster… - Human molecular …, 2017 - academic.oup.com
Genetic association studies provide evidence for a substantial polygenic component to
schizophrenia, although the neurobiological mechanisms underlying the disorder remain …
schizophrenia, although the neurobiological mechanisms underlying the disorder remain …
Identification of schizophrenia-associated loci by combining DNA methylation and gene expression data from whole blood
KR Van Eijk, S De Jong, E Strengman… - European Journal of …, 2015 - nature.com
Emerging evidence suggests that schizophrenia (SZ) susceptibility involves variation at
genetic, epigenetic and transcriptome levels. We describe an integrated approach that …
genetic, epigenetic and transcriptome levels. We describe an integrated approach that …
Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex
DNA methylation (DNAm) is important in brain development and is potentially important in
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …
Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia
Background Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to
result from disturbances in early brain development. There is mounting evidence to support …
result from disturbances in early brain development. There is mounting evidence to support …
Association of DNA methylation differences with schizophrenia in an epigenome-wide association study
Importance DNA methylation may play an important role in schizophrenia (SZ), either
directly as a mechanism of pathogenesis or as a biomarker of risk. Objective To scan …
directly as a mechanism of pathogenesis or as a biomarker of risk. Objective To scan …
Schizophrenia-associated differential DNA methylation in brain is distributed across the genome and annotated to MAD1L1, a locus at which DNA methylation and …
BC McKinney, LL McClain, CM Hensler, Y Wei… - Translational …, 2022 - nature.com
DNA methylation (DNAm), the addition of a methyl group to a cytosine in DNA, plays an
important role in the regulation of gene expression. Single-nucleotide polymorphisms …
important role in the regulation of gene expression. Single-nucleotide polymorphisms …
DNA methylation in schizophrenia: progress and challenges of epigenetic studies
Schizophrenia is a severe psychiatric disease affecting about 1% of the world's population,
with significant effects on patients and society. Genetic studies have identified several …
with significant effects on patients and society. Genetic studies have identified several …
Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults
Importance Epigenetic studies present unique opportunities to advance schizophrenia
research because they can potentially account for many of its clinical features and suggest …
research because they can potentially account for many of its clinical features and suggest …