Neuropathic corneal pain: approaches for management

G Dieckmann, S Goyal, P Hamrah - Ophthalmology, 2017 - Elsevier
Neuropathic pain is caused by a primary lesion or dysfunction of the nervous system and
can occur in the cornea. However, neuropathic corneal pain (NCP) is currently an ill-defined …

Understanding neuropathic corneal pain—gaps and current therapeutic approaches

S Goyal, P Hamrah - Seminars in ophthalmology, 2016 - Taylor & Francis
The richly innervated corneal tissue is one of the most powerful pain generators in the body.
Corneal neuropathic pain results from dysfunctional nerves causing perceptions such as …

Low-dose naltrexone is effective and well-tolerated for modulating symptoms in patients with neuropathic corneal pain

G Dieckmann, MC Ozmen, SM Cox, RC Engert… - The ocular …, 2021 - Elsevier
Purpose Neuropathic corneal pain (NCP) is caused by damage or disease of the
somatosensory nervous system that innervates the cornea and presents with symptoms of …

Ocular neuropathic pain: an overview focusing on ocular surface pains

N Ebrahimiadib, F Yousefshahi, P Abdi… - Clinical …, 2020 - Taylor & Francis
Objective This paper reviews ocular pain with the main focus on ocular surface discomfort
and dry eye pain. Anatomy, physiology, epidemiology, assessment, and treatment are …

Coexistence of neuropathic corneal pain, corneal nerve abnormalities, depression, and low quality of life

A Leonardi, OM Feuerman, E Salami, D Lazzarini… - Eye, 2024 - nature.com
Purpose To evaluate the quality of life (QoL), mental health conditions and corneal
morphology in neuropathic corneal pain (NCP) subjects without a significant ocular surface …

Ocular surface pain: a narrative review

D Mehra, NK Cohen, A Galor - Ophthalmology and therapy, 2020 - Springer
Ocular surface pain is a frequent cause of visits to an eye care provider and has a
substantial impact on healthcare cost, yet a complete understanding of its causative factors …

Role of corneal nerves in ocular surface homeostasis and disease

M Labetoulle, C Baudouin, M Calonge… - Acta …, 2019 - Wiley Online Library
Corneal nerves are key components of the physiological system that controls ocular surface
homeostasis. The cornea is primarily innervated by the ophthalmic branch of the trigeminal …

Efficacy of autologous serum tears for treatment of neuropathic corneal pain

S Aggarwal, C Colon, A Kheirkhah, P Hamrah - The ocular surface, 2019 - Elsevier
Objective Corneal nerve damage may result in neuropathic corneal pain (NCP). Autologous
serum tears (AST) have been shown to results in nerve regeneration and may help alleviate …

Ocular neuropathic pain

P Rosenthal, D Borsook - British Journal of Ophthalmology, 2016 - bjo.bmj.com
As the biological alarm of impending or actual tissue damage, pain is essential for our
survival. However, when it is initiated and/or sustained by dysfunctional elements in the …

Neuropathic ocular pain: an important yet underevaluated feature of dry eye

A Galor, RC Levitt, ER Felix, ER Martin… - Eye, 2015 - nature.com
Dry eye has gained recognition as a public health problem given its prevalence, morbidity,
and cost implications. Dry eye can have a variety of symptoms including blurred vision …