One-carbon metabolism and Alzheimer's disease: is it all a methylation matter?

A Fuso, S Scarpa - Neurobiology of aging, 2011 - Elsevier
The sporadic form of Alzheimer disease, late onset Alzheimer's disease (LOAD), is a
multifactorial disease; a strong link between nutritional and genetic factors with normal aging …

Alzheimer's disease pathogenesis: Is there a role for folate?

N Robinson, P Grabowski, I Rehman - Mechanisms of ageing and …, 2018 - Elsevier
Epigenetic modifications, including changes in DNA methylation, have been implicated in a
wide range of diseases including neurological diseases such as Alzheimer's. The role of …

Homocysteine metabolism and the associations of global DNA methylation with selected gene polymorphisms and nutritional factors in patients with dementia

M Bednarska-Makaruk, A Graban… - Experimental …, 2016 - Elsevier
Epigenetics (particularly DNA methylation) together with environmental and genetic factors,
are key to understanding the pathogenesis of many diseases including dementia …

Abnormal homocysteine metabolism: an insight of Alzheimer's disease from DNA methylation

T Pi, B Liu, J Shi - Behavioural Neurology, 2020 - Wiley Online Library
Alzheimer's disease (AD) is a chronic neurodegenerative disease in the central nervous
system that has complex pathogenesis in the elderly. The current review focuses on the …

Folate, homocysteine, vitamin B12, and polymorphisms of genes participating in one-carbon metabolism in late-onset Alzheimer's disease patients and healthy …

F Coppedè, P Tannorella, I Pezzini… - Antioxidants & Redox …, 2012 - liebertpub.com
Aims: We screened 378 late-onset Alzheimer's disease (LOAD) patients and 308 matched
controls for the presence of the common MTHFR 677C> T, MTRR 66A> G, MTR 2756 A> G …

Environment, epigenetics and neurodegeneration: focus on nutrition in Alzheimer's disease

V Nicolia, M Lucarelli, A Fuso - Experimental Gerontology, 2015 - Elsevier
Many different environmental factors (nutrients, pollutants, chemicals, physical activity,
lifestyle, physical and mental stress) can modulate epigenetic markers in the developing and …

Hyperhomocysteinemia in Alzheimer's disease: the hen and the egg?

M Farkas, S Keskitalo, DEC Smith… - Journal of …, 2013 - content.iospress.com
Hyperhomocysteinemia is associated with Alzheimer's disease (AD). The causality of this
association is controversial. In this study we tested the effect of a hyperhomocysteinemia …

Artificial neural networks link one-carbon metabolism to gene-promoter methylation in Alzheimer's disease

E Grossi, A Stoccoro, P Tannorella… - Journal of …, 2016 - content.iospress.com
Background: There is increasing interest in DNA methylation studies in Alzheimer's disease
(AD), but little is still known concerning the relationship between gene-promoter methylation …

One-carbon metabolism and Alzheimer's disease: focus on epigenetics

F Coppedè - Current genomics, 2010 - ingentaconnect.com
Alzheimer's disease (AD) represents the most common form of dementia in the elderly,
characterized by progressive loss of memory and cognitive capacity severe enough to …

Nutritional factors and Alzheimer's disease

W Reynish, S Andrieu, F Nourhashemi… - The Journals of …, 2001 - academic.oup.com
Nutritional factors are integrally linked with Alzheimer's disease (AD). Although AD patients
have no changes in energy metabolism, fluctuations in weight are fairly common. The …