Objectives The habenula is a brain structure implicated in depression, yet with unknown
molecular mechanisms. Several phosphodiesterases (PDEs) have been associated with a …

The habenula is a paired epithalamic structure involved in the pathogenesis of major
depressive disorder (MDD). Evidence comes from its impact on the regulation of …

The habenula is an evolutionarily conserved structure in the vertebrate brain. Lesion and
electrophysiological studies in animals have suggested that it is involved in the regulation of …

The habenula (Hb) can play an important role in major depressive disorder (MDD) as it is a
key node between fronto-limbic areas and midbrain monoaminergic structures. In vivo …

Background Habenula, a hub brain region controlling monoaminergic brain center, has
been implicated in major depressive disorder (MDD) and as a possible target of …

BACKGROUND:: Increased activity of the habenula has been implicated in the etiology of
major depressive disorder (MDD), in which reductions in habenula volume are present after …

Background: The thalamus and habenula are thought to be key brain regions in the etiology
of major depressive disorder (MDD); however, few studies have investigated the structural …

Background Major depressive disorder (MDD) is a common cause of disability and
morbidity, affecting about 10% of the population worldwide. Subclinical depression (SD) can …

The habenula (Hb) has been hypothesized to play an essential role in major depressive
disorder (MDD) as it is considered to be an important node between fronto-limbic areas and …

Background: The habenula is an epithalamic brain structure that acts as a neuroanatomical
hub connecting the limbic forebrain to the major monoamine centres. Abnormal habenula …