S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological
methyl donor synthesized in all mammalian cells but most abundantly in the liver …

Abstract S‐Adenosylmethionine (SAMe), the principal biological methyl donor, is
synthesized from methionine and ATP in a reaction catalyzed by methionine …

Genome sequence analysis reveals that all organisms synthesize S-adenosylmethionine
(AdoMet) and that a large fraction of all genes is AdoMet-dependent methyltransferases …

Liver-specific and nonliver-specific methionine adenosyltransferases (MATs) are products of
two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S …

S-Adenosylmethionine (SAMe) has rapidly moved from being a methyl donor to a key
metabolite that regulates hepatocyte growth, death, and differentiation. Biosynthesis of …

Methionine catabolism occurs mostly in the liver through the formation of S-
adenosylmethionine (SAM) in a reaction catalyzed by methionine adenosyltransferase …

In mammals, methionine adenosyltransferase (MAT), the enzyme responsible for S-
adenosylmethionine (AdoMet) synthesis, is encoded by two genes, MAT1A and MAT2A. In …

Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of
two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S …

Alterations of methionine cycle in steatohepatitis, cirrhosis, and hepatocellular carcinoma
induce MAT1A decrease and MAT2A increase expressions with the consequent decrease of …

Methionine metabolism starts with the formation of S-adenosylmethionine (AdoMet), the
most important biological methyl donor. This reaction is catalyzed by methionine …