The human leukocyte antigen (HLA) haplotype DRB1* 15: 01 is the major risk factor for
multiple sclerosis (MS). Here, we find that DRB1* 15: 01 is hypomethylated and …

Background Although many genetic variants have been associated with multiple sclerosis
(MS) risk, they do not explain all the disease risk and there remains uncertainty as to how …

Background: Multiple sclerosis (MS) is thought to be caused by T-cell mediated autoimmune
dysfunction. Risk of developing MS is influenced by environmental and genetic factors …

Variation in major histocompatibility complex genes on chromosome 6p21. 3, specifically the
human leukocyte antigen HLA-DR2 or DRB1* 1501-DQB1* 0602 extended haplotype …

Genetic susceptibility to multiple sclerosis (MS) is associated with the MHC located on
chromosome 6p21. This signal maps primarily to a 1-Mb region encompassing the HLA …

Background: The association between multiple sclerosis (MS) and the HLA-DRB1* 15: 01
haplotype has been proven to be strong, but its molecular basis remains unclear. Vitamin D …

The human leukocyte antigen (HLA) DRB1* 1501 has been consistently associated with
multiple sclerosis (MS) in nearly all populations tested. This points to a specific antigen …

Models of disease susceptibility in multiple sclerosis (MS) often assume a dominant action
for the HLA-DRB1* 1501 allele and its associated haplotype (DRB1* 1501-DQB1* 0602 or …

A recent high-density linkage screen confirmed that the HLA complex contains the strongest
genetic factor for the risk of multiple sclerosis (MS). In parallel, a linkage disequilibrium …

Multiple sclerosis (MS), a common central nervous system inflammatory disease, has a
major heritable component. Susceptibility is associated with the MHC class II region …