Loss of the de novo DNA methyltransferases Dnmt3a and Dnmt3b in embryonic stem cells
obstructs differentiation; however, the role of these enzymes in somatic stem cells is largely …

Epigenetic regulation of hematopoietic stem cells (HSCs) ensures lifelong production of
blood and bone marrow. Recently, we reported that loss of de novo DNA methyltransferase …

DNA methylation is essential for development and in diverse biological processes. The DNA
methyltransferase Dnmt1 maintains parental cell methylation patterns on daughter DNA …

DNA methylation is a key epigenetic modification involved in regulating gene expression
and maintaining genomic integrity. Here we inactivated all three catalytically active DNA …

DNA methylation is an epigenetic modification essential for development. The DNA
methyltransferases Dnmt3a and Dnmt3b execute de novo DNA methylation in gastrulating …

DNA methylation is an epigenetic modification associated with transcriptional repression of
promoters and is essential for mammalian development. Establishment of DNA methylation …

DNA methylation by de novo DNA methyltransferases 3A (DNMT3A) and 3B (DNMT3B) at
cytosines is essential for genome regulation and development,. Dysregulation of this …

Abstract DNMT3L (DNMT3-like), a member of the DNMT3 family, has no DNA
methyltransferase activity but regulates de novo DNA methylation. While biochemical …

Abstract DNA methyltransferase 3A (DNMT3A) is mutated in hematologic malignancies
affecting myeloid, mixed, and lymphoid lineages, and these mutations are associated with …

Gains and losses in DNA methylation are prominent features of mammalian cell types. To
gain insight into the mechanisms that promote shifts in DNA methylation and contribute to …