Gut microbiota‐derived metabolite trimethylamine N‐oxide (TMAO) potentially increases the risk of obesity in adults: An exploratory systematic review and dose …

P Dehghan, MA Farhangi, L Nikniaz, Z Nikniaz… - Obesity …, 2020 - Wiley Online Library
It has been suggested that trimethylamine N‐oxide (TMAO) is associated with increased risk
of diabetes and cardiovascular disease (CVD) morbidity and mortality. However, it is not …

[HTML][HTML] Gut microbiota–derived metabolite trimethylamine-N-oxide and multiple health outcomes: an umbrella review and updated meta-analysis

D Li, Y Lu, S Yuan, X Cai, Y He, J Chen, Q Wu… - The American journal of …, 2022 - Elsevier
ABSTRACT Background Trimethylamine-N-oxide (TMAO) is a gut microbiota–derived
metabolite produced from dietary nutrients. Many studies have discovered that circulating …

[HTML][HTML] The gut microbial metabolite trimethylamine N-oxide and hypertension risk: a systematic review and dose–response meta-analysis

X Ge, L Zheng, R Zhuang, P Yu, Z Xu, G Liu, X Xi… - Advances in …, 2020 - Elsevier
The gut microbial metabolite trimethylamine N-oxide (TMAO) is increasingly regarded as a
novel risk factor for cardiovascular events and mortality. However, little is known about the …

Gut microbe–generated metabolite trimethylamine N‐oxide and the risk of diabetes: A systematic review and dose‐response meta‐analysis

R Zhuang, X Ge, L Han, P Yu, X Gong, Q Meng… - Obesity …, 2019 - Wiley Online Library
Elevated circulating concentrations of the gut bacteria choline metabolite trimethylamine N‐
oxide (TMAO) were found in patients with type 2 diabetes mellitus (T2DM). However …

Novel findings of the association between gut microbiota–derived metabolite trimethylamine N-oxide and inflammation: results from a systematic review and dose …

MA Farhangi, M Vajdi - Critical reviews in food science and …, 2020 - Taylor & Francis
The gut microbiota–derived metabolite trimethylamine N-oxide (TMAO) has been regarded
as one of the potent risk factors of cardiovascular events and diabetes. However, its …

[HTML][HTML] Associations of plasma trimethylamine N-oxide, choline, carnitine, and betaine with inflammatory and cardiometabolic risk biomarkers and the fecal …

BC Fu, MAJ Hullar, TW Randolph, AA Franke… - The American journal of …, 2020 - Elsevier
ABSTRACT Background Trimethylamine N-oxide (TMAO), a compound derived from diet
and metabolism by the gut microbiome, has been associated with several chronic diseases …

Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis

GG Schiattarella, A Sannino, E Toscano… - European heart …, 2017 - academic.oup.com
Aims Gut microbiota-derived metabolite trimethylamine-N-oxide (TMAO) is emerging as a
new potentially important cause of increased cardiovascular risk. The purpose of this meta …

[HTML][HTML] Circulating trimethylamine N-oxide in association with diet and cardiometabolic biomarkers: an international pooled analysis

JJ Yang, XO Shu, DM Herrington, SC Moore… - The American journal of …, 2021 - Elsevier
ABSTRACT Background Trimethylamine N-oxide (TMAO), a diet-derived, gut microbial-host
cometabolite, has been linked to cardiometabolic diseases. However, the relations remain …

Gut microbiota-derived TMAO: a causal factor promoting atherosclerotic cardiovascular disease?

M Canyelles, C Borràs, N Rotllan, M Tondo… - International journal of …, 2023 - mdpi.com
Trimethylamine-N-oxide (TMAO) is the main diet-induced metabolite produced by the gut
microbiota, and it is mainly eliminated through renal excretion. TMAO has been correlated …

Gut microbiota-associated metabolite trimethylamine N-Oxide and the risk of stroke: a systematic review and dose–response meta-analysis

MA Farhangi, M Vajdi, M Asghari-Jafarabadi - Nutrition journal, 2020 - Springer
Aims Several epidemiological studies have examined the association between
trimethylamine N-Oxide (TMAO) and stroke risk; however, the results are still inconclusive …