With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

Alzheimer's disease (AD) is the leading cause of dementia in the United States and afflicts>
5.7 million Americans in 2018. Therapeutic options remain extremely limited to those that …

Diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) arise from
complex interactions of genetic and environmental factors, with genetic variants regulating …

Introduction Environmental factors are poorly understood in the etiology of Alzheimer's
disease (AD) and related dementias. The importance of environmental factors in gene …

To provide better prevention and treatment, we need to understand the environmental and
genetic risks of Alzheimer's disease (AD). However, the definition of AD has been …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder whose clinical
manifestations appear in old age. The hallmark pathological features of AD (amyloid …

Alzheimer's disease (AD) is a sporadic, chronic neurodegenerative disease, usually
occurring late in life. The last decade has witnessed tremendous advances in our …

Alzheimer's disease (AD) is a clinically heterogeneous neurodegenerative disease with a
strong genetic component. Several genes have been associated with AD risk for nearly 20 …

At present, the etiology of Alzheimer's disease (AD) is still unclear, but both genetic and non-
genetic factors are thought to take part in the etiopathogenesis of AD. Epidemiologic …

Multifactorial diseases are characterized by inter-individual variation in etiology, age of
onset, and penetrance. These diseases tend to be relatively common and arise from the …