Epigenetic modification of gene expression in cancer cells by terahertz demethylation

H Cheon, JK Hur, W Hwang, HJ Yang, JH Son - Scientific Reports, 2023 - nature.com
Terahertz (THz) radiation can affect the degree of DNA methylation, the spectral
characteristics of which exist in the terahertz region. DNA methylation is an epigenetic …

Detection and manipulation of methylation in blood cancer DNA using terahertz radiation

H Cheon, JH Paik, M Choi, HJ Yang, JH Son - Scientific reports, 2019 - nature.com
DNA methylation is a pivotal epigenetic modification of DNA that regulates gene expression.
Abnormal regulation of gene expression is closely related to carcinogenesis, which is why …

Effective demethylation of melanoma cells using terahertz radiation

H Cheon, HJ Yang, M Choi, JH Son - Biomedical Optics Express, 2019 - opg.optica.org
Terahertz (THz) demethylation is a photomedical technique applied to dissociate methyl-
DNA bonds and reduce global DNA methylation using resonant THz radiation. We …

[HTML][HTML] Potential clinical applications of terahertz radiation

JH Son, SJ Oh, H Cheon - Journal of Applied Physics, 2019 - pubs.aip.org
Terahertz radiation has significant potential in medical diagnosis and treatment because its
frequency range corresponds to the characteristic energy of biomolecular motion …

Terahertz molecular resonance of cancer DNA

H Cheon, H Yang, SH Lee, YA Kim, JH Son - Scientific Reports, 2016 - nature.com
Carcinogenesis involves the chemical and structural alteration of biomolecules in cells.
Aberrant methylation of DNA is a well-known carcinogenic mechanism and a common …

[HTML][HTML] Inhibition of cancer cell migration and glycolysis by terahertz wave modulation via altered chromatin accessibility

L Sun, Y Li, Y Yu, P Wang, S Zhu, K Wu, Y Liu, R Wang… - Research, 2022 - spj.science.org
Metastasis and metabolic disorders contribute to most cancer deaths and are potential drug
targets in cancer treatment. However, corresponding drugs inevitably induce myeloid …

Terahertz Photons Inhibit Cancer Cells Long Term by Suppressing Nano Telomerase Activity

J Yin, K Wu, Y Yu, Y Zhong, Z Song, C Chang, G Liu - ACS nano, 2024 - ACS Publications
Telomeres are nanoscale DNA–protein complexes to protect and stabilize chromosomes.
The reexpression of telomerase in cancer cells is a key determinant crucial for the infinite …

Intense THz pulses cause H2AX phosphorylation and activate DNA damage response in human skin tissue

LV Titova, AK Ayesheshim, A Golubov… - Biomedical optics …, 2013 - opg.optica.org
Recent emergence and growing use of terahertz (THz) radiation for medical imaging and
public security screening raise questions on reasonable levels of exposure and health …

Study of the effects of 0.15 terahertz radiation on genome integrity of adult fibroblasts

V Franchini, S De Sanctis, J Marinaccio… - Environmental and …, 2018 - Wiley Online Library
The applications of Terahertz (THz) technologies have significantly developed in recent
years, and the complete understanding of the biological effects of exposure to THz radiation …

Terahertz radiation: a non-contact tool for the selective stimulation of biological responses in human cells

I Echchgadda, JE Grundt, CZ Cerna… - IEEE Transactions …, 2015 - ieeexplore.ieee.org
Collective motions of water and of many biological macromolecules have characteristic time
scales on the order of a picosecond. As a result, these biomolecules can strongly absorb …