Visible‐light‐induced annihilation of tumor cells with platinum–porphyrin conjugates

A Naik, R Rubbiani, G Gasser… - Angewandte Chemie, 2014 - Wiley Online Library
Despite the extensive use of porphyrins in photodynamic therapy (PDT), tetraplatinated
porphyrins have so far not been studied for their anticancer properties. Herein, we report the …

Hematoporphyrin-derived soluble porphyrin− platinum conjugates with combined cytotoxic and phototoxic antitumor activity

C Lottner, KC Bart, G Bernhardt… - Journal of Medicinal …, 2002 - ACS Publications
To combine the cytotoxic activity of cisplatin and the phototoxicicity of hematoporphyrin
derivatives in the same molecule, hematoporphyrin was derivatized at the two secondary …

A folate-conjugated platinum porphyrin complex as a new cancer-targeting photosensitizer for photodynamic therapy

M Yang, J Deng, D Guo, J Zhang, L Yang… - Organic & Biomolecular …, 2019 - pubs.rsc.org
A new folate-conjugated platinum porphyrin complex (Por 4) was synthesized and
characterized. The singlet oxygen production of the conjugates was evaluated through a 1, 3 …

Palladium porphyrin complexes for photodynamic cancer therapy: Effect of porphyrin units and metal

J Deng, H Li, M Yang, F Wu - Photochemical & Photobiological Sciences, 2020 - Springer
Photodynamic therapy (PDT) has been extensively explored for malignant tissue treatment.
In this work, we successfully synthesized and characterized a series of porphyrin …

Conjugates of porphyrinoid-based photosensitizers with cytotoxic drugs: current progress and future directions toward selective photodynamic therapy

VF Otvagin, NS Kuzmina, ES Kudriashova… - Journal of medicinal …, 2022 - ACS Publications
Photodynamic therapy (PDT) is a treatment modality where light-mediated activation of
photosensitizers in a patient's body leads to the generation of cytotoxic reactive oxygen …

Soluble tetraarylporphyrin− platinum conjugates as cytotoxic and phototoxic antitumor agents

C Lottner, KC Bart, G Bernhardt… - Journal of medicinal …, 2002 - ACS Publications
A series of asymmetric tetraarylporphyrins was synthesized from pyrrole, para-substituted
oligo-or poly (ethylene glycol) monomethyl ether benzaldehyde and from 4 …

Photoinduced cytotoxicity and biodistribution of prostate cancer cell-targeted porphyrins

I Sehgal, M Sibrian-Vazquez - Journal of medicinal chemistry, 2008 - ACS Publications
A series of five porphyrin− peptide conjugates bearing one or two sequences containing a
cell penetrating peptide (CPP), a nuclear localization signal (NLS), or a bifunctional CPP …

Porphyrin and nonporphyrin photosensitizers in oncology: preclinical and clinical advances in photodynamic therapy

AE O'Connor, WM Gallagher… - Photochemistry and …, 2009 - Wiley Online Library
Photodynamic therapy (PDT) is now a well‐recognized modality for the treatment of cancer.
While PDT has developed progressively over the last century, great advances have been …

The role of porphyrin chemistry in tumor imaging and photodynamic therapy

M Ethirajan, Y Chen, P Joshi, RK Pandey - Chemical Society Reviews, 2011 - pubs.rsc.org
In recent years several review articles and books have been published on the use of
porphyrin-based compounds in photodynamic therapy (PDT). This critical review is focused …

Ruthenium− porphyrin conjugates with cytotoxic and phototoxic antitumor activity

T Gianferrara, A Bergamo, I Bratsos… - Journal of medicinal …, 2010 - ACS Publications
We report here two novel “extended-arms” porphyrins, TetbpyPP and TedabpyPP, in which
four peripheral bpy fragments are connected to the meso positions of the macrocycle …