A reappraisal of the mucoactive activity and clinical efficacy of bromhexine

A Zanasi, M Mazzolini, A Kantar - Multidisciplinary respiratory medicine, 2017 - Springer
Since its introduction to the market in 1963, bromhexine, an over-the-counter drug, has been
investigated for its activity in animal models and in humans with diverse respiratory …

A between-patient, double-blind comparison of S-carboxymethylcysteine and bromhexine in chronic obstructive bronchitis

M Aylward - Current Medical Research and Opinion, 1973 - Taylor & Francis
S-carboxymethylcysteine was compared with bromhexine in a double-blind between-patient
clinical trial in bronchiticpatients with mucoid sputum. Oral S-carboxymethylcysteine …

Beyond the lungs: exploring diverse applications of bromhexine and ambroxol

E Ahmadi, A Afrooghe, ZE Soltani, M Elahi, M Shayan… - Life Sciences, 2024 - Elsevier
The respiratory tract is commonly affected in multisystem disorders. Although many drugs
have been developed to target various components of these diseases, there is still a need …

Effects of baicalin and wogonin on mucin release from cultured airway epithelial cells

HJ Heo, HJ Lee, YS Kim, SS Kang… - … Journal Devoted to …, 2007 - Wiley Online Library
Scutellaria baicalensis Georgi has been used for the treatment of diverse chronic
inflammatory diseases including respiratory disease in oriental medicine and its major …

Mucoactive agents in the therapy of upper respiratory airways infections: fair to describe them just as mucoactive?

F Scaglione, O Petrini - Clinical Medicine Insights: Ear, Nose …, 2019 - journals.sagepub.com
Background: Upper and lower respiratory tract infections are common conditions for which
medical advice is sought, and their management relies on the use of prescription and over …

Role of bromhexine in exacerbations of bronchiectasis: double-blind randomized multicenter study versus placebo

D Olivieri, A Ciaccia, E Marangio, S Marsico, T Todisco… - Respiration, 1991 - karger.com
The effectiveness of bromhexine in the treatment of patients with bronchiectasis, in a stage
of clinical exacerbation, was assessed in a double-blind, placebo-controlled trial involving …

Clinical effectiveness of a combination of bromhexine and amoxicillin in lower respiratory tract infection. A randomized controlled trial.

CC Roa Jr, RB Dantes - Arzneimittel-forschung, 1995 - europepmc.org
A multicenter double-blind randomized trial was performed in 22 teaching hospitals to
compare the clinical effectiveness of the combination of amoxicillin (CAS 26787-78-0) plus …

Clinical results in the treatment of chronic obstructive bronchitis with ambroxol in comparison with bromhexine (author's transl)

KJ Wiessmann, K Niemeyer - Arzneimittel-forschung, 1978 - europepmc.org
Preclinical studies of trans-4-[(2-amino-3, 5-dibromobenzyl)-amino]-cyclohexanol
hydrochloride (ambroxol, NA 872), the metabolite VIII of bromhexine, show that it is superior …

Enhancement of lung levels of antibiotics by ambroxol and bromhexine

V Deretic, GS Timmins - Expert opinion on drug metabolism & …, 2019 - Taylor & Francis
Introduction: Major unmet needs remain for improved antibiotic treatment in lung infections.
While development of new antibiotics is needed to overcome resistance, other approaches …

Ambroxol: a multifaceted molecule with additional therapeutic potentials in respiratory disorders of childhood

D Paleari, GA Rossi, G Nicolini… - Expert opinion on drug …, 2011 - Taylor & Francis
Introduction: Mucoactive drugs are currently used to cleanse the respiratory tract following
disturbance of the normal mucociliary clearance due to mucous hyperproduction and/or …