Delayed administration IL-1β neutralizing antibody improves cognitive function after transient global ischemia in rats
B Zhao, C Zou, P Zhou - Behavioural brain research, 2016 - Elsevier
In order to study the protective effects on motor and cognitive function by inhibiting IL-1β as
delayed as 24 h after global ischemia, we designed behavioral testing protocol and …
delayed as 24 h after global ischemia, we designed behavioral testing protocol and …
Effects of rat anti-mouse interleukin-6 receptor antibody on the recovery of cognitive function in stroke mice
J Wei, C Sun, C Liu, Q Zhang - Cellular and Molecular Neurobiology, 2018 - Springer
This study aimed to investigate the effects of rat anti-mouse interleukin (IL)-6 receptor
antibody (MR16-1) on the recovery of cognitive function in stroke mice. Adult male C57BL/6 …
antibody (MR16-1) on the recovery of cognitive function in stroke mice. Adult male C57BL/6 …
The Single-Dose Application of Interleukin-4 Ameliorates Secondary Brain Damage in the Early Phase after Moderate Experimental Traumatic Brain Injury in Mice
J Walter, J Mende, S Hutagalung, OT Alhalabi… - International Journal of …, 2023 - mdpi.com
Activation of the interleukin-4 (IL-4) pathway ameliorates secondary injury mechanisms after
experimental traumatic brain injury (TBI); therefore, we assessed the effect of a therapeutic …
experimental traumatic brain injury (TBI); therefore, we assessed the effect of a therapeutic …
The Akt/glycogen synthase kinase-3β pathway participates in the neuroprotective effect of interleukin-4 against cerebral ischemia/reperfusion injury
M Li, WW Gao, L Liu, Y Gao, YF Wang… - Neural regeneration …, 2020 - journals.lww.com
Abstract Interleukin-4 (IL-4) has a protective effect against cerebral ischemia/reperfusion
injury. Animal experiments have shown that IL-4 improves the short-and long-term prognosis …
injury. Animal experiments have shown that IL-4 improves the short-and long-term prognosis …
Increased brain injury and worsened neurological outcome in interleukin-4 knockout mice after transient focal cerebral ischemia
Background and Purpose—Stroke causes brain injury with activation of an inflammatory
response that can contribute to injury. We tested the hypothesis that the anti-inflammatory …
response that can contribute to injury. We tested the hypothesis that the anti-inflammatory …
Neutralization of interleukin‐1β reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice
F Clausen, A Hånell, C Israelsson… - European Journal of …, 2011 - Wiley Online Library
Increasing evidence suggests that interleukin‐1β (IL‐1β) is a key mediator of the
inflammatory response following traumatic brain injury (TBI). Recently, we showed that …
inflammatory response following traumatic brain injury (TBI). Recently, we showed that …
Neutralization of interleukin‐1β modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice
F Clausen, A Hånell, M Björk, L Hillered… - European Journal of …, 2009 - Wiley Online Library
Abstract Interleukin‐1β (IL‐1β) may play a central role in the inflammatory response
following traumatic brain injury (TBI). We subjected 91 mice to controlled cortical impact …
following traumatic brain injury (TBI). We subjected 91 mice to controlled cortical impact …
Role of IL-1α and IL-1β in ischemic brain damage
H Boutin, RA LeFeuvre, R Horai, M Asano… - Journal of …, 2001 - Soc Neuroscience
The cytokine interleukin-1 (IL-1) has been strongly implicated in the pathogenesis of
ischemic brain damage. Evidence to date suggests that the major form of IL-1 contributing to …
ischemic brain damage. Evidence to date suggests that the major form of IL-1 contributing to …
Interleukin 15 blockade protects the brain from cerebral ischemia-reperfusion injury
GA Lee, TN Lin, CY Chen, SY Mau, WZ Huang… - Brain, Behavior, and …, 2018 - Elsevier
Acute ischemic stroke is followed by a complex interplay between the brain and the immune
system in which ischemia-reperfusion leads to a detrimental inflammatory response that …
system in which ischemia-reperfusion leads to a detrimental inflammatory response that …
Early exercise after intracerebral hemorrhage inhibits inflammation and promotes neuroprotection in the sensorimotor cortex in rats
K Tamakoshi, K Hayao, H Takahashi - Neuroscience, 2020 - Elsevier
The present study examined the effect of early exercise on brain damage and recovery of
motor function following intracerebral hemorrhage (ICH) in rats. Subjects were randomly …
motor function following intracerebral hemorrhage (ICH) in rats. Subjects were randomly …