Beginning with precursor lesions, aberrant DNA methylation marks the entire spectrum of
prostate cancer progression. We mapped the global DNA methylation patterns in select …

Candidate gene-based studies have identified a handful of aberrant CpG DNA methylation
events in prostate cancer. However, DNA methylation profiles have not been compared on a …

DNA methylation is one of the most important epigenetic mechanisms in regulating gene
expression. Genome hypermethylation has been proposed as a critical mechanism in …

Background Aberrant DNA methylation may promote prostate carcinogenesis. We
investigated epigenome‐wide DNA methylation profiles in prostate cancer (PCa) compared …

A critical need in understanding the biology of prostate cancer is characterizing the
molecular differences between indolent and aggressive cases. Because DNA methylation …

Background Current diagnostic tools for prostate cancer lack specificity and sensitivity for
detecting very early lesions. DNA methylation is a stable genomic modification that is …

Although prostate cancer (PCa) is the second leading cause of cancer death among men
worldwide, not all men diagnosed with PCa will die from the disease. A critical challenge …

Abstract Background Prostate cancer (PCa) remains the second leading cause of deaths
due to cancer in the United States in men. The aim of this study was to perform an integrative …

DNA methylation primarily occurs at CpG dinucleotides in mammals and is a common
epigenetic mark that plays a critical role in the regulation of gene expression. Profiling DNA …

Many differentially methylated genes have been identified in prostate cancer (PCa),
primarily using candidate gene-based assays. Recently, several global DNA methylation …