Mechanisms of Pulmonary Escape and Dissemination by Cryptococcus neoformans

ST Denham, JCS Brown - Journal of Fungi, 2018 - mdpi.com
Cryptococcus neoformans is a common environmental saprophyte and human fungal
pathogen that primarily causes disease in immunocompromised individuals. Similar to many …

Cryptococcus–Epithelial Interactions

LM Taylor-Smith - Journal of Fungi, 2017 - mdpi.com
The fungal pathogen, Cryptococcus neoformans, causes devastating levels of morbidity and
mortality. Infections with this fungus tend to be predominantly in immunocompromised …

Dueling in the lung: how Cryptococcus spores race the host for survival

MR Botts, CM Hull - Current opinion in microbiology, 2010 - Elsevier
Many human fungal pathogens infect people when they are inhaled as spores. Despite the
serious impact of fungal spores on human health, little is known about their basic properties …

Paradoxical roles of alveolar macrophages in the host response to Cryptococcus neoformans

TJ McQuiston, PR Williamson - Journal of Infection and Chemotherapy, 2012 - Elsevier
Cryptococcus neoformans (Cn) is a fungal pathogen that is a serious health threat to
immunocompromised individuals. Upon environmental exposure, infectious fungal …

Pulmonary Macrophage and Dendritic Cell Responses to Cryptococcus neoformans

BN Nelson, AN Hawkins, KL Wozniak - Frontiers in cellular and …, 2020 - frontiersin.org
The fungal pathogen Cryptococcus neoformans can cause life-threatening infections in
immune compromised individuals. This pathogen is typically acquired via inhalation, and …

A dissemination-prone morphotype enhances extrapulmonary organ entry by Cryptococcus neoformans

ST Denham, B Brammer, KY Chung, MA Wambaugh… - Cell host & …, 2022 - cell.com
Environmental pathogens move from ecological niches to mammalian hosts, requiring
adaptation to dramatically different environments. Microbes that disseminate farther …

New insights on the pathogenesis of invasive Cryptococcus neoformans infection

HC Eisenman, A Casadevall, EE McClelland - Current Infectious Disease …, 2007 - Springer
Disseminated cryptococcosis begins with infection of the lungs via inhalation. This is
followed by escape from the lungs and entry into the bloodstream allowing dissemination to …

Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host

MS Price, M Betancourt-Quiroz, JL Price, DL Toffaletti… - MBio, 2011 - Am Soc Microbiol
Cryptococcus neoformans is an important fungal pathogen of immunocompromised
individuals, with a close relative, Cryptococcus gattii, emerging as a serious threat for the …

The tools for virulence of Cryptococcus neoformans

C Coelho, AL Bocca, A Casadevall - Advances in applied microbiology, 2014 - Elsevier
Cryptococcus neoformans is a fungal pathogen that causes almost half a million deaths
each year. It is believed that most humans are infected with C. neoformans, possibly in a …

Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box

JW Kronstad, R Attarian, B Cadieux, J Choi… - Nature reviews …, 2011 - nature.com
Cryptococcus neoformans is generally considered to be an opportunistic fungal pathogen
because of its tendency to infect immunocompromised individuals, particularly those …