A paucity of data exists on the disposition and effect of drugs in young children. This
information gap can be reduced by elucidating developmental principles of absorption …

Advances in the basic and clinical sciences of drug actions and safety have been applied
almost exclusively to the largest demographic patient group–adults. Metabolism-dependent …

The maturation of organ systems during fetal life and childhood exerts a profound effect on
drug disposition. The maturation of drug-metabolising enzymes is probably the predominant …

The aim of this review is to discuss our current understanding of the developmental changes
of the drug-metabolizing enzyme cytochrome P450 (CYP) 3A and its impact on drug therapy …

First‐dose‐in‐children relies on the prediction of clearance from adults for which little
information is available on the accuracy of the scaling‐approaches applied. For CYP3A …

From birth, children may need to take medication for acute or chronic diseases. Antibiotics,
anti-asthmatic drugs, antihistamines, analgesics, gastrointestinal drugs and attention …

The goal of pharmacogenomics is to comprehend the effect of inter-individual genetic
variations on the outcome of treatment.[1, 2] By understanding the role that these genetic …

Pharmacokinetics varies widely between children. Many factors play an important role in this
variability, such as ontogeny, pharmacogenetics, gender, comorbidities, and drug-drug …

CYP2D6 substrates are among the most highly prescribed medications in teenagers and
also commonly associated with serious adverse events. To investigate the relative …

Abstract Background and Objectives Current cytochrome P450 (CYP) 1A2 and 3A4
ontogeny profiles, which are derived mainly from in vitro studies and incorporated in …