Alzheimer's disease (AD) is characterized by synaptic failure, dendritic and axonal atrophy,
neuronal death and progressive loss of cognitive functions. It is commonly assumed that …

Cleavage of the amyloid precursor protein (APP) by α-secretase generates an extracellularly
released fragment termed secreted APP-alpha (APPsα). Not only is this process of interest …

The key role of APP in the pathogenesis of Alzheimer disease is well established. However,
postnatal lethality of double knockout mice has so far precluded the analysis of the …

The recent availability of transgenic mouse models of Alzheimer disease has allowed direct
in vivo assessment of the molecular and neuropathological effects of cerebral amyloid …

Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by
extracellular plaques containing amyloid β (Aβ)-protein and intracellular tangles containing …

Alzheimer's disease (AD) is a neurodegenerative disease driven in large part by
accumulated deposits in the brain of the amyloid precursor protein (APP) cleavage product …

Alzheimer's disease (AD) may be caused by the abnormal processing of the amyloid
precursor protein (APP) and the accumulation of β-amyloid (Aβ). The amyloid precursor …

It is well established that the proteolytic processing of the β-amyloid precursor protein (APP)
generates β-amyloid (Aβ), which plays a central role in the pathogenesis of Alzheimer's …

The amyloid precursor protein family (APP/APLPs) has essential roles for neuromuscular
synapse development and for the formation and plasticity of synapses within the CNS …

One of the most extensively used transgenic mouse model of Alzheimer's disease (AD) is
APPswe/PS1dE9 mice, which over express the Swedish mutation of APP together with PS1 …