The down regulation of glutamic acid decarboxylase67 (GAD1), reelin (RELN), and BDNF
expression in brain of schizophrenia (SZ) and bipolar (BP) disorder patients is associated …

Several lines of schizophrenia (SZ) research suggest that a functional downregulation of the
prefrontal cortex GABAergic neuronal system is mediated by a promoter hypermethylation …

In the cerebral prefrontal cortex (PFC), DNA-methyltransferase 1 (DNMT1), the enzyme that
catalyzes the methylation of cytosine at carbon atoms in position 5 in CpG dinucleotides, is …

The epigenetic dysregulation of the brain genome associated with the clinical manifestations
of schizophrenia (SZ) includes altered DNA promoter methylation of several candidate …

Cortical DNA-methyltransferase 1 (DNMT1) is preferentially expressed in interneurons
secreting GABA where it very likely contributes to promoter CpG island hypermethylation …

Objective: Consistent evidence indicated that aberrant DNA methylation may be involved in
the development of schizophrenia. DNA methyltransferase 3B (DNMT3B) is the key …

Aberrant transcriptional regulation may be one of the key components of the
pathophysiology of mood disorders. DNA methylation generally acts as an epigenetic gene …

Bipolar Disorder (BD) is a prevalent and disabling condition, determined by gene-
environment interactions, possibly mediated by epigenetic mechanisms. The present study …

Major psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BP) with
psychosis (BP+) express a complex symptomatology characterized by positive symptoms …

BACKGROUND: Epigenetic mechanisms may be involved in the reprogramming of gene
expression in response to stressful stimuli. This investigation determined whether epigenetic …