NR4A3: a key nuclear receptor in vascular biology, cardiovascular remodeling, and beyond

J Martínez-González, L Cañes, J Alonso… - International journal of …, 2021 - mdpi.com
The mechanisms committed in the activation and response of vascular and inflammatory
immune cells play a major role in tissue remodeling in cardiovascular diseases (CVDs) such …

Nuclear receptor NOR-1 (neuron-derived orphan receptor-1) in pathological vascular remodelling and vascular remodelling

C Ballester-Servera, L Cañes, J Alonso… - Clínica e Investigación …, 2022 - Elsevier
Vascular cells and their interaction with inflammatory cells and the immune system play a
key role in pathological vascular remodeling. A large number of genes and proteins …

NR4A orphan nuclear receptors in cardiovascular biology

Y Zhao, D Bruemmer - Drug Discovery Today: Disease Mechanisms, 2009 - Elsevier
The NR4A orphan nuclear receptor subfamily comprises the highly homologous receptors
Nur77 (NR4A1), Nurr1 (NR4A2) and NOR1 (NR4A3). These evolutionarily conserved and …

NR4A nuclear receptors in immunity and atherosclerosis

AAJ Hamers, RN Hanna, H Nowyhed… - Current opinion in …, 2013 - journals.lww.com
These exciting, novel insights on the function of NR4A nuclear receptors in immunity,
vascular cells and atherosclerosis will initiate a plethora of studies to understand the …

NR4A nuclear receptors in atherosclerosis and vein-graft disease

PI Bonta, TWH Pols, CJM de Vries - Trends in cardiovascular medicine, 2007 - Elsevier
Nur77, Nurr1, and NOR-1 form the NR4A subfamily of the nuclear hormone receptor
superfamily of transcription factors and have been described in the regulation of …

The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation

T Nomiyama, T Nakamachi, F Gizard… - Journal of Biological …, 2006 - ASBMB
Members of the nuclear hormone receptor superfamily function as key transcriptional
regulators of inflammation and proliferation in cardiovascular diseases. In addition to the …

NR4A orphan nuclear receptors: transcriptional regulators of gene expression in metabolism and vascular biology

Y Zhao, D Bruemmer - Arteriosclerosis, thrombosis, and vascular …, 2010 - Am Heart Assoc
Members of the nuclear hormone receptor superfamily, including the peroxisome proliferator–
activated receptor and the liver X receptor subfamilies, orchestrate transcriptional networks …

NR4All in the vessel wall

CM van Tiel, CJM de Vries - The Journal of steroid biochemistry and …, 2012 - Elsevier
A number of nuclear receptors are involved in maintenance of normal vessel wall physiology
as well as in pathophysiological processes such as atherosclerosis, restenosis and …

NR4A nuclear orphan receptors: protective in vascular disease?

TWH Pols, PI Bonta, CJM de Vries - Current opinion in lipidology, 2007 - journals.lww.com
NR4A nuclear orphan receptors: protective in vascular diseas... : Current Opinion in Lipidology
NR4A nuclear orphan receptors: protective in vascular disease? : Current Opinion in Lipidology …

Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis

Y Zhao, DA Howatt, F Gizard, T Nomiyama… - Circulation …, 2010 - Am Heart Assoc
Rationale: The orphan nuclear receptor NOR1 is a member of the evolutionary highly
conserved and ligand-independent NR4A subfamily of the nuclear hormone receptor …