Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

M Kou, L Huang, J Yang, Z Chiang, S Chen, J Liu… - Cell death & …, 2022 - nature.com
Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone
marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and …

Mesenchymal stem cell-derived extracellular vesicles: a novel cell-free therapy

M Jafarinia, F Alsahebfosoul, H Salehi… - Immunological …, 2020 - Taylor & Francis
In recent years, mesenchymal stem/stromal cells (MSCs) have widely been considered as
therapeutic tools in basic researches and clinical trials. Accumulating evidence supports the …

Mesenchymal stem cell-derived extracellular vesicles: challenges in clinical applications

A Gowen, F Shahjin, S Chand, KE Odegaard… - Frontiers in cell and …, 2020 - frontiersin.org
Stem cell therapy has garnered much attention and application in the past decades for the
treatment of diseases and injuries. Mesenchymal stem cells (MSCs) are studied most …

Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications

S Rani, AE Ryan, MD Griffin, T Ritter - Molecular Therapy, 2015 - cell.com
Mesenchymal stem (stromal) cells (MSCs) are multipotent cells with the ability to differentiate
into several cell types, thus serving as a cell reservoir for regenerative medicine. Much of the …

[HTML][HTML] Stem cell-derived extracellular vesicles as immunomodulatory therapeutics

Y Seo, HS Kim, IS Hong - Stem cells international, 2019 - hindawi.com
Mesenchymal stem cells (MSCs) have been reported to possess regulatory functions on
immune cells which make them alternative therapeutics for the treatment of inflammatory …

Mesenchymal stromal cell-derived extracellular vesicles for regenerative therapy and immune modulation: Progress and challenges toward clinical application

D Allan, A Tieu, M Lalu, D Burger - Stem Cells Translational …, 2020 - academic.oup.com
Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) have emerged
as a promising form of regenerative therapy and immune modulation. Fundamental …

Mesenchymal stem cell-derived extracellular vesicles alter disease outcomes via endorsement of macrophage polarization

J Wang, J Xia, R Huang, Y Hu, J Fan, Q Shu… - Stem Cell Research & …, 2020 - Springer
Mesenchymal stem cells (MSCs) are adult stromal cells that reside in virtually all postnatal
tissues. Due to their regenerative and immunomodulatory capacities, MSCs have attracted …

Enhancement of therapeutic potential of mesenchymal stem cell-derived extracellular vesicles

KS Park, E Bandeira, GV Shelke, C Lässer… - Stem cell research & …, 2019 - Springer
After the initial investigations into applications of mesenchymal stem cells (MSCs) for cell
therapy, there was increased interest in their secreted soluble factors. Following studies of …

[HTML][HTML] Immunomodulatory and regenerative effects of mesenchymal stem cells and extracellular vesicles: therapeutic outlook for inflammatory and degenerative …

S Dabrowska, A Andrzejewska, M Janowski… - Frontiers in …, 2021 - frontiersin.org
Mesenchymal stem cells (MSCs) are non-hematopoietic, multipotent stem cells derived from
mesoderm, which can be easily isolated from many sources such as bone marrow, umbilical …

[HTML][HTML] Therapeutic application of mesenchymal stem cells derived extracellular vesicles for immunomodulation

MO Gomzikova, V James, AA Rizvanov - Frontiers in immunology, 2019 - frontiersin.org
The immunosuppressive potential of mesenchymal stem cells has been extensively
investigated in many studies in vivo and in vitro. In recent years, a variety preclinical and …