The structure of the polycystic kidney disease channel PKD2 in lipid nanodiscs
Summary The Polycystic Kidney Disease 2 (Pkd2) gene is mutated in autosomal dominant
polycystic kidney disease (ADPKD), one of the most common human monogenic disorders …
polycystic kidney disease (ADPKD), one of the most common human monogenic disorders …
Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1
Abstract PKD2L1, also termed TRPP3 from the TRPP subfamily (polycystic TRP channels),
is involved in the sour sensation and other pH-dependent processes. PKD2L1 is believed to …
is involved in the sour sensation and other pH-dependent processes. PKD2L1 is believed to …
Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease
H Ding, LX Li, PC Harris, J Yang, X Li - Nature communications, 2021 - nature.com
Autosomal dominant polycystic kidney disease (ADPKD) is caused by germline mutations of
PKD1 or PKD2 on one allele and a somatic mutation inactivating the remaining normal …
PKD1 or PKD2 on one allele and a somatic mutation inactivating the remaining normal …
Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene
C Boulter, S Mulroy, S Webb… - Proceedings of the …, 2001 - National Acad Sciences
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by cyst formation
in the kidney, liver, and pancreas and is associated often with cardiovascular abnormalities …
in the kidney, liver, and pancreas and is associated often with cardiovascular abnormalities …
Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium
Mutations in the polycystin genes, PKD1 or PKD2, results in Autosomal Dominant Polycystic
Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack a …
Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack a …
Mutations of PKD1 in ADPKD2 cysts suggest a pathogenic effect of trans-heterozygous mutations
T Watnick, N He, K Wang, Y Liang, P Parfrey… - Nature …, 2000 - nature.com
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1
and PKD2. The products of these genes associate to form heteromeric complexes. Several …
and PKD2. The products of these genes associate to form heteromeric complexes. Several …
Somatic mutations in renal cyst epithelium in autosomal dominant polycystic kidney disease
AY Tan, T Zhang, A Michaeel… - Journal of the …, 2018 - journals.lww.com
Background Autosomal dominant polycystic kidney disease (ADPKD) is a ciliopathy caused
by mutations in PKD1 and PKD2 that is characterized by renal tubular epithelial cell …
by mutations in PKD1 and PKD2 that is characterized by renal tubular epithelial cell …
Scattered deletion of PKD1 in kidneys causes a cystic snowball effect and recapitulates polycystic kidney disease
WN Leonhard, M Zandbergen, K Veraar… - Journal of the …, 2015 - journals.lww.com
In total, 1 in 1000 individuals carries a germline mutation in the PKD1 or PKD2 gene, which
leads to autosomal dominant polycystic kidney disease (ADPKD). Cysts can form early in life …
leads to autosomal dominant polycystic kidney disease (ADPKD). Cysts can form early in life …
Polycystic kidney disease: the complete structure of the PKD1 gene and its protein
International Polycystic Kidney Disease Consortium - Cell, 1995 - Elsevier
Mutations in the PKD1 gene are the most common cause of autosomal dominant polycystic
kidney disease (ADPKD). Other PKD1-like loci on chromosome 16 are approximately 97 …
kidney disease (ADPKD). Other PKD1-like loci on chromosome 16 are approximately 97 …
Polycystic kidney disease: new understanding in the pathogenesis
PD Wilson - The international journal of biochemistry & cell biology, 2004 - Elsevier
Polycystic kidney disease (PKD) is a disease of the nephron, characterized by the formation
of multiple renal tubular cysts, leading to endstage renal failure. The most common form is …
of multiple renal tubular cysts, leading to endstage renal failure. The most common form is …