Assessing DNA methylation profiles in human blood has become a major focus of
epidemiologic inquiry. Understanding variability in CpG-specific DNA methylation over …

Background: Between-and within-person variation in DNA methylation levels are important
parameters to be considered in epigenome-wide association studies. Temporal change is …

Cytosine-5 methylation within CpG dinucleotides is a potentially important mechanism of
epigenetic influence on human traits and disease. In addition to influences of age and …

Background DNA methylation is a dynamic epigenetic mechanism that occurs at cytosine-
phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) …

The reliability of methylation measures from the widely used HumanMethylation450
(HM450K) microarray has not been assessed for DNA from dried blood spots (DBS) or …

Illumina BeadChips are widely utilized in epigenome-wide association studies (EWAS).
Several studies have reported that many probes on these arrays have poor reliability. Here …

Aim: We examined concordance of methylation levels across the Illumina Infinium
HumanMethylation450 BeadChip and the Infinium MethylationEPIC BeadChip. Methods …

The need for research investigating DNA methylation (DNAm) in clinical studies has
increased, leading to the evolution of new analytic methods to improve accuracy and …

Epigenome-wide association studies, which searches for blood-based DNA methylation
signatures associated with environmental exposures and/or disease susceptibilities, is a …

Methylation of CpG dinucleotides is a mitotically heritable and highly stable epigenetic
mechanism fundamental to cellular differentiation. Establishment of cell type-specific DNA …