Microglia are the brain's resident macrophages, which guide various developmental
processes crucial for brain maturation, activity, and plasticity. Microglial progenitors enter the …

The development and maintenance of the central nervous system is dependent upon
regulated, homeostatic actions of microglia, which sculpt and refine neuronal circuitry. By …

Microglia were first recognized as a distinct cell population in the CNS one century ago. For
a long time, they were primarily considered to be phagocytes responsible for removing …

Microglia are the resident immune effector cells of the central nervous system (CNS) rapidly
reacting to any perturbation in order to maintain CNS homeostasis. Although their …

There has been an explosion of new findings recently giving us insights into the involvement
of microglia in central nervous system (CNS) disorders. A host of new molecular tools and …

Microglia are the resident immune cells of the central nervous system (CNS) and are
increasingly recognized as critical players in development, brain homeostasis, and disease …

A century after Cajal identified a “third element” of the nervous system, many issues have
been clarified about the identity and function of one of its major components, the microglia …

It has been nearly a century since the early description of microglia by Rio-Hortega; since
then many more biological and pathological features of microglia have been recognized …

Highlights•Ontogeny, local cues and body signals drive microglial identity and functional
state.•Microglia display developmental heterogeneity.•Novel microglial functions include …

Originally hypothesized to function solely as immunologic responders within the central
nervous system (CNS), emerging evidence has revealed that microglia have more complex …