Bivalent chromatin is characterized by the simultaneous presence of H3K4me3 and
H3K27me3, histone modifications generally associated with transcriptionally active and …

Bivalent (poised or paused) chromatin comprises activating and repressing histone
modifications at the same location. This combination of epigenetic marks at promoter or …

Background: Development is an epigenetic regulation dependent event. As one
pretranscriptional regulator, bivalent histone modifications were observed to be involved in …

An intricate molecular machinery is at the core of gene expression regulation in every cell.
During the initial stages of organismal development, the coordinated activation of diverse …

Epigenetic modifications on the chromatin do not occur in isolation. Chromatin-associated
proteins and their modification products form a highly interconnected network, and …

Constitutive heterochromatin is typically defined by high levels of DNA methylation and H3
lysine 9 trimethylation (H3K9Me3), whereas facultative heterochromatin displays DNA …

Chromatin is separated into functional domains distinguished by combinatorial patterns of
post-translational histone modifications and DNA methylation. Recent studies examining …

Many DNA-hypermethylated cancer genes are occupied by the Polycomb (PcG) repressor
complex in embryonic stem cells (ESCs). Their prevalence in the full spectrum of cancers …

Heterochromatin is integral to cell identity maintenance by impeding the activation of genes
for alternate cell fates. Heterochromatic regions are associated with histone 3 lysine 9 …

Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …