Epigenetic changes associated with histone modifications play an important role in the
emergence and maintenance of the phenotype of various cancer types. In contrast to direct …

Among the epigenetic changes, histone acetylation has been recognized as a fundamental
process that strongly affects gene expression regulation. Disrupt of this phenomenon has …

Epigenetic regulations play a crucial role in the expression of various genes that are
important in the normal cell function. Any alteration in these epigenetic mechanisms can …

The genetic changes leading to the development of human cancer are accompanied by
alterations in the structure and modification status of chromatin, which represent powerful …

Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …

Post-translational modification of histones provides an important regulatory platform for
processes such as gene expression, DNA replication and repair, chromosome condensation …

Histones are the main structural proteins of eukaryotic chromatin. Histone acetylation/
deacetylation are the epigenetic mechanisms of the regulation of gene expression and are …

Posttranslational modifications to histones affect chromatin structure and function resulting in
altered gene expression and changes in cell behavior. Aberrant gene expression and …

DNA in eukaryotic cells is packaged into chromatin. The main packaging component of
chromatin is the nucleosome, and this is composed of proteins known as histones. Histones …

Cancer in humans is the result of a multi-step process. This process often involves the
activation of oncogenes and/or the inactivation of tumor suppressor genes. These two steps …