In mammals, DNA methylation occurs mainly at CpG dinucleotides. Methylation of the
promoter suppresses gene expression, but the functional role of gene-body DNA …

Enzymes that catalyse CpG methylation in DNA, including the DNA methyltransferases 1
(DNMT1), 3A (DNMT3A) and 3B (DNMT3B), are indispensable for mammalian tissue …

Mammalian cells stably maintain high levels of DNA methylation despite expressing both
positive (DNMT3A/B) and negative (TET1-3) regulators. Here, we analyzed the independent …

DNA methylation is an epigenetic modification associated with transcriptional repression of
promoters and is essential for mammalian development. Establishment of DNA methylation …

DNA methylation was first described almost a century ago; however, the rules governing its
establishment and maintenance remain elusive. Here we present data demonstrating that …

DNA methylation is extensively reprogrammed during the early phases of mammalian
development, yet genomic targets of this process are largely unknown. We optimized …

DNA methylation at proximal promoters facilitates lineage restriction by silencing cell type–
specific genes. However, euchromatic DNA methylation frequently occurs in regions outside …

Mouse embryos acquire global DNA methylation of their genome during implantation.
However the exact roles of DNA methyltransferases (DNMTs) in embryos have not been …

Background DNA methylation patterns are initiated by de novo DNA methyltransferases
DNMT3a/3b adding methyl groups to CG dinucleotides in the hypomethylated genome of …

Background DNA methylation is a heritable epigenetic mark, enabling stable but reversible
gene repression. In mammalian cells, DNA methyltransferases (DNMTs) are responsible for …