Consistent gene signature of schizophrenia identified by a novel feature selection strategy from comprehensive sets of transcriptomic data

Q Yang, B Li, J Tang, X Cui, Y Wang, X Li… - Briefings in …, 2020 - academic.oup.com
The etiology of schizophrenia (SCZ) is regarded as one of the most fundamental puzzles in
current medical research, and its diagnosis is limited by the lack of objective molecular …

Schizophrenia gene networks and pathways and their applications for novel candidate gene selection

J Sun, P Jia, AH Fanous, E van den Oord, X Chen… - PloS one, 2010 - journals.plos.org
Background Schizophrenia (SZ) is a heritable, complex mental disorder. We have seen
limited success in finding causal genes for schizophrenia from numerous conventional …

Identifying crucial biomarkers in peripheral blood of schizophrenia and screening therapeutic agents by comprehensive bioinformatics analysis

M Xie, Z Li, X Li, L Ai, M Jin, N Jia, Y Yang, W Li… - Journal of psychiatric …, 2022 - Elsevier
Schizophrenia (SCZ) is a sophisticated neurodevelopmental disorder, but the mechanisms
remain ambiguous. Thus, we analyzed the transcriptomic datasets to investigate the …

Integrative omics of schizophrenia: from genetic determinants to clinical classification and risk prediction

F Guan, T Ni, W Zhu, LK Williams, LB Cui, M Li… - Molecular …, 2022 - nature.com
Schizophrenia (SCZ) is a debilitating neuropsychiatric disorder with high heritability and
complex inheritance. In the past decade, successful identification of numerous susceptibility …

SZGR: a comprehensive schizophrenia gene resource

P Jia, J Sun, AY Guo, Z Zhao - Molecular psychiatry, 2010 - nature.com
Schizophrenia is a major debilitating psychiatric disorder affecting∼ 1% of the population
worldwide. A tremendous amount of effort has been expended in the last two decades to …

A multi-dimensional evidence-based candidate gene prioritization approach for complex diseases–schizophrenia as a case

J Sun, P Jia, AH Fanous, BT Webb… - …, 2009 - academic.oup.com
Motivation: During the past decade, we have seen an exponential growth of vast amounts of
genetic data generated for complex disease studies. Currently, across a variety of complex …

SZDB: a database for schizophrenia genetic research

Y Wu, YG Yao, XJ Luo - Schizophrenia bulletin, 2017 - academic.oup.com
Schizophrenia (SZ) is a debilitating brain disorder with a complex genetic architecture.
Genetic studies, especially recent genome-wide association studies (GWAS), have identified …

Identification of potential biomarkers and their correlation with immune infiltration cells in schizophrenia using combinative bioinformatics strategy

Z Li, X Li, M Jin, Y Liu, Y He, N Jia, X Cui, Y Liu, G Hu… - Psychiatry …, 2022 - Elsevier
Many studies have identified changes in gene expression in brains of schizophrenia
patients and their altered molecular processes, but the findings in different datasets were …

Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data

P Jia, L Wang, HY Meltzer, Z Zhao - Schizophrenia research, 2010 - Elsevier
Unlike the typical analysis of single markers in genome-wide association studies (GWAS),
we incorporated Gene Set Enrichment Analysis (GSEA) and hypergeometric test and …

Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results

AL Collins, Y Kim, P Sklar, MC O'Donovan… - Psychological …, 2012 - cambridge.org
BackgroundCandidate gene studies have been a key approach to the genetics of
schizophrenia (SCZ). However, the results of these studies are confusing and no genes …