Vascular smooth muscle cells phenotypic switching in cardiovascular diseases

HY Tang, AQ Chen, H Zhang, XF Gao, XQ Kong… - Cells, 2022 - mdpi.com
Vascular smooth muscle cells (VSMCs), the major cell type in the arterial vessel wall, have a
contractile phenotype that maintains the normal vessel structure and function under …

An update on the phenotypic switching of vascular smooth muscle cells in the pathogenesis of atherosclerosis

F Zhang, X Guo, Y Xia, L Mao - Cellular and Molecular Life Sciences, 2022 - Springer
Vascular smooth muscle cells (VSMCs) are involved in phenotypic switching in
atherosclerosis. This switching is characterized by VSMC dedifferentiation, migration, and …

[HTML][HTML] Targeting smooth muscle cell phenotypic switching in vascular disease

R Chakraborty, P Chatterjee, JM Dave, AC Ostriker… - JVS-vascular …, 2021 - Elsevier
Objective The phenotypic plasticity of vascular smooth muscle cells (VSMCs) is central to
vessel growth and remodeling, but also contributes to cardiovascular pathologies. New …

How vascular smooth muscle cell phenotype switching contributes to vascular disease

G Cao, X Xuan, J Hu, R Zhang, H Jin… - Cell Communication and …, 2022 - Springer
Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier
experiments have found that VSMCs possess high plasticity. Vascular injury stimulates …

Role of vascular smooth muscle cell phenotype switching in arteriogenesis

JV Ashraf, A Al Haj Zen - International journal of molecular sciences, 2021 - mdpi.com
Arteriogenesis is one of the primary physiological means by which the circulatory collateral
system restores blood flow after significant arterial occlusion in peripheral arterial disease …

[HTML][HTML] Role of smooth muscle cells in Cardiovascular Disease

Y Zhuge, J Zhang, F Qian, Z Wen, C Niu… - … journal of biological …, 2020 - ncbi.nlm.nih.gov
Normally, smooth muscle cells (SMCs) are localized in the tunica media of the vasculature,
where they take responsibility for vascular contraction and extracellular matrix (ECM) …

Fate and state of vascular smooth muscle cells in atherosclerosis

JM Miano, EA Fisher, MW Majesky - Circulation, 2021 - Am Heart Assoc
Vascular smooth muscle cells (VSMCs) have long been associated with phenotypic
modulation/plasticity or dedifferentiation. Innovative technologies in cell lineage tracing …

Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity

A Frismantiene, M Philippova, P Erne, TJ Resink - Cellular signalling, 2018 - Elsevier
Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessels. Unlike
many other mature cell types in the adult body, VSMC do not terminally differentiate but …

Single-cell genomics reveals a novel cell state during smooth muscle cell phenotypic switching and potential therapeutic targets for atherosclerosis in mouse and …

H Pan, C Xue, BJ Auerbach, J Fan, AC Bashore, J Cui… - Circulation, 2020 - Am Heart Assoc
Background: Smooth muscle cells (SMCs) play significant roles in atherosclerosis via
phenotypic switching, a pathological process in which SMC dedifferentiation, migration, and …

Smooth muscle cells in vascular remodeling

N Shi, X Mei, SY Chen - Arteriosclerosis, thrombosis, and vascular …, 2019 - Am Heart Assoc
As the primary causes of myocardial infarction, stroke, atherosclerosis, in-stent restenosis,
and aneurysm, aortic diseases pose a serious threat to human health. Arterial remodeling is …