A host of cancer types exhibit aberrant histone modifications. Recently, distinct and recurrent
mutations in a specific histone variant, histone H3. 3, have been implicated in a high …

Recurrent missense mutations in histone H3 were recently reported in pediatric gliomas and
soft tissue tumors. Strikingly, these mutations only affected a minority of the total cellular H3 …

In this review, we describe the attributes of histone H3 mutants identified in cancer. H3
mutants were first identified in genes encoding H3. 3, in pediatric high-grade glioma, and …

Histone proteins wrap around DNA to form nucleosomes, which further compact into the
higher-order structure of chromatin. In addition to the canonical histones, there are also …

The building block of chromatin is nucleosome, which consists of 146 base pairs of DNA
wrapped around a histone octamer composed of two copies of histone H2A, H2B, H3, and …

Although somatic mutations in Histone 3.3 (H3. 3) are well-studied drivers of oncogenesis,
the role of germline mutations remains unreported. We analyze 46 patients bearing de novo …

Histone variants are key players in shaping chromatin structure, and, thus, in regulating
fundamental cellular processes such as chromosome segregation and gene expression …

Histone variant H3. 3 plays novel roles in development as compared to canonical H3
proteins and is the most commonly mutated histone protein of any kind in human disease …

Until recently, mutations in histones had not been described in any human disease.
However, genome-wide sequencing of pediatric high-grade gliomas revealed somatic …

Genes encoding histone proteins are recurrently mutated in tumor samples, and these
mutations may impact nucleosome stability, histone post-translational modification, or …