Abstract Development of resistance to TRAIL-induced toxicity is one of the strategies used
from tumor cells to escape destruction from the immune system. This process may occur …

Activation of cell surface death receptors by their cognate ligands triggers apoptosis. Several
human death receptors (Fas, TNF-R1, TRAMP, DR4, DR5, DR6, EDA-R and NGF-R) have …

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine and a
selective inducer of apoptosis in a range of tumour cells, but not in normal, untransformed …

Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) can induce apoptosis
in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any …

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also known as
Apo2L, is a member of the TNF superfamily (TNFSF) of cytokines. TRAIL gained much …

Simple Summary The mechanisms of leukemic cell resistance to antitumor immunity
remains a topical issue. In this work, we found an increase in TRAIL-resistance of human …

Tumor necrosis factor-associated ligand inducing apoptosis (TRAIL) induces apoptosis
through the death receptors (DRs) 4 and 5 expressed on the cell surface. Upon ligand …

Abstract mAbs were generated against the extracellular domain of the four known TNF-
related apoptosis-inducing ligand (TRAIL) receptors and tested on a panel of human …

Abstract Treatment of cancer patients with conventional therapies (chemotherapy, hormonal
therapy, immunotherapy and radiation) respond initially well and experience prolonged …

Prominent among cell surface molecules capable of initiating apoptosis are members of the
tumour necrosis factor (TNF) family of ligands and receptors. Death-inducing members of the …