Aberrant methylation is one of the most frequent epigenetic alterations that can contribute to
tumor formation. Cell-free DNA can originate from tumor tissue; therefore, the evaluation of …

AIM: To investigate the feasibility of detecting methylated fecal DNA as a screening tool for
colorectal carcinoma (CRC) and precancerous lesions. METHODS: Methylated secreted …

Purpose: To identify epigenetic molecular makers in plasma for the early detection of
colorectal cancer. Experimental Design: We retrospectively analyzed the methylation status …

Background Colorectal cancer (CRC) development is accompanied by changes in
expression for several genes; but the details of the underlying regulatory procesess remain …

Aberrantly methylated genes are increasingly being established as biomarkers for the
detection of colorectal cancer (CRC). In the present study, the methylation levels of the …

DNA methylation is a key mechanism of colorectal carcinogenesis. Analysis of aberrantly
methylation in stool DNA might provide a novel strategy for noninvasive detection of …

Microarray analysis of promoter hypermethylation provides insight into the role and extent of
DNA methylation in the development of colorectal cancer (CRC) and may be co-monitored …

Background Two molecular pathways promote the development of colorectal cancer (CRC).
One is termed “microsatellite stable”(MSS) whereas the other is characterized by …

Colorectal cancer (CRC) arises from accumulated genetic and epigenetic alterations, which
provide the possibility to identify tumor-specific biomarkers by analyzing fecal DNA …

Introduction DNA methylation of secreted frizzled-related proteins (SFRPs) can be detected
in colorectal cancer (CRC) tissue, in tissue of adenomas, and in aberrant crypt foci, whereas …