Antithrombotic therapy in abdominal aortic aneurysm: beneficial or detrimental?

SJ Cameron, HM Russell… - Blood, The Journal of the …, 2018 - ashpublications.org
Abdominal aortic aneurysm (AAA) is a degenerative vascular pathology resulting in
significant morbidity and mortality in older adults due to rupture and sudden death. Despite …

[HTML][HTML] Thrombus volume is similar in patients with ruptured and intact abdominal aortic aneurysms

J Golledge, V Iyer, J Jenkins, B Bradshaw… - Journal of vascular …, 2014 - Elsevier
Objective Most abdominal aortic aneurysms (AAAs) contain intraluminal thrombus (ILT),
which has been demonstrated to contain proteolytic enzymes and proinflammatory cytokines …

Current status and perspectives on pharmacologic therapy for abdominal aortic aneurysm

K Yoshimura, N Morikage… - Current drug …, 2018 - ingentaconnect.com
Background: Abdominal aortic aneurysm (AAA), a common disease involving the segmental
expansion and rupture of the aorta, has a high mortality rate. Therapeutic options for AAA …

Atherosclerosis and abdominal aortic aneurysm: cause, response, or common risk factors?

J Golledge, PE Norman - Arteriosclerosis, thrombosis, and …, 2010 - Am Heart Assoc
Abdominal aortic aneurysm (AAA) rupture has been recognized as a significant cause of
mortality for adults aged 60 years in the developed world for some time. 1 AAAs are usually …

[HTML][HTML] Development of pharmacotherapies for abdominal aortic aneurysms

LM Weaver, CD Loftin, CG Zhan - Biomedicine & Pharmacotherapy, 2022 - Elsevier
The cardiovascular field is still searching for a treatment for abdominal aortic aneurysms
(AAA). This inflammatory disease often goes undiagnosed until a late stage and associated …

[HTML][HTML] Novel pharmacological approaches in abdominal aortic aneurysm

L Puertas-Umbert, R Almendra-Pegueros… - Clinical …, 2023 - portlandpress.com
Abdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health
issue with an unmet medical need for therapy. This disease is featured by a progressive …

[HTML][HTML] Challenges and opportunities in limiting abdominal aortic aneurysm growth

J Golledge, PE Norman, MP Murphy… - Journal of vascular …, 2017 - Elsevier
Objective This review describes ongoing efforts to develop a medical therapy to limit
abdominal aortic aneurysm (AAA) growth. Methods Data from animal model studies, human …

Disseminated intravascular coagulopathy in aortic aneurysms

A Fernandez-Bustamante, A Jimeno - European Journal of Internal …, 2005 - Elsevier
Aneurysm-induced disseminated intravascular coagulopathy (DIC) constitutes a rare
presentation form of aortic aneurysms. The majority of DIC cases are asymptomatic and this …

Pathogenesis and management of abdominal aortic aneurysm

J Golledge, S Thanigaimani, JT Powell… - European Heart …, 2023 - academic.oup.com
Abdominal aortic aneurysm (AAA) causes∼ 170 000 deaths annually worldwide. Most
guidelines recommend asymptomatic small AAAs (30 to< 50 mm in women; 30 to< 55 mm in …

[HTML][HTML] Intraluminal thrombus: Innocent bystander or factor in abdominal aortic aneurysm pathogenesis?

AJ Boyd - JVS-Vascular Science, 2021 - Elsevier
Abstract Background Abdominal aortic aneurysms (AAAs) represent a complex multifactorial
hemodynamic, thrombotic, and inflammatory process that can ultimately result in aortic …