Cryptococcal antigenemia in advanced human immunodeficiency virus disease: pathophysiology, epidemiology, and clinical implications

RM Wake, SF Molloy, JN Jarvis… - Clinical Infectious …, 2023 - academic.oup.com
Cryptococcal antigen (CrAg) is detectable in blood prior to the onset of symptomatic
cryptococcal meningitis (CM), a leading cause of death among people with advanced …

High cryptococcal antigen titers in blood are predictive of subclinical cryptococcal meningitis among human immunodeficiency virus-infected patients

RM Wake, E Britz, C Sriruttan, I Rukasha… - Clinical Infectious …, 2018 - academic.oup.com
Background High mortality rates among asymptomatic cryptococcal antigen (CrAg)–positive
patients identified through CrAg screening, despite preemptive fluconazole treatment, may …

Cryptococcal antigenemia is associated with meningitis or death in HIV-infected adults with CD4 100–200 cells/mm3

J Wykowski, SR Galagan, S Govere, CL Wallis… - BMC Infectious …, 2020 - Springer
Abstract Background Cryptococcal antigen (CrAg) screening with fluconazole prophylaxis
has been shown to prevent cryptococcal meningitis and mortality for people living with HIV …

Cryptococcal antigenemia in human immunodeficiency virus antiretroviral therapy–experienced Ugandans with virologic failure

E Mpoza, R Rajasingham, L Tugume… - Clinical Infectious …, 2020 - academic.oup.com
Background Detectable serum or plasma cryptococcal antigen (CrAg) precedes
symptomatic cryptococcal meningitis. The World Health Organization recommends CrAg …

[HTML][HTML] Prevalence and correlates of cryptococcal antigen positivity among AIDS patients—United States, 1986–2012

J McKenney, RM Smith, TM Chiller, R Detels… - MMWR Morb Mortal …, 2014 - cdc.gov
Cryptococcal meningitis (CM) is one of the leading opportunistic infections associated with
human immunodeficiency virus (HIV) infection (1). The worldwide burden of CM among …

Asymptomatic cryptococcal antigenemia is associated with mortality among HIV‐positive patients in Indonesia

AR Ganiem, AR Indrati, R Wisaksana… - Journal of the …, 2014 - Wiley Online Library
Introduction Previous studies, mostly from Africa, have shown that serum cryptococcal
antigenemia may precede the development of cryptococcal meningitis and early death …

Symptomatic cryptococcal antigenemia presenting as early cryptococcal meningitis with negative cerebral spinal fluid analysis

K Ssebambulidde, AS Bangdiwala… - Clinical Infectious …, 2019 - academic.oup.com
Background Individuals with cryptococcal antigenemia are at high risk of developing
cryptococcal meningitis if untreated. The progression and timing from asymptomatic infection …

Prevalence and factors associated with cryptococcal antigenemia among severely immunosuppressed HIV-infected adults in Uganda: a cross-sectional study

J Oyella, D Meya, F Bajunirwe, MR Kamya - Journal of the International …, 2012 - Springer
Background Cryptococcal infection is a common opportunistic infection among severely
immunosuppressed HIV patients and is associated with high mortality. Positive cryptococcal …

Cryptococcal-related mortality despite fluconazole preemptive treatment in a cryptococcal antigen screen-and-treat program

RM Wake, NP Govender, T Omar, C Nel… - Clinical Infectious …, 2020 - academic.oup.com
Abstract Background Cryptococcal antigen (CrAg) screening and treatment with preemptive
fluconazole reduces the incidence of clinically evident cryptococcal meningitis in individuals …

Reflexive laboratory-based cryptococcal antigen screening and preemptive fluconazole therapy for cryptococcal antigenemia in HIV-infected individuals with CD4< …

DB Meya, AN Kiragga, E Nalintya… - JAIDS Journal of …, 2019 - journals.lww.com
Background: HIV-infected persons with cryptococcal antigenemia (CrAg) are at high risk for
meningitis or death. We evaluated the effect of CrAg screening and preemptive fluconazole …