In many cancers, tumour progression is associated with increased tissue stiffness. Yet, the
mechanisms associating tissue stiffness with tumorigenesis and malignant transformation …

Defining the interplay between the genetic events and microenvironmental contexts
necessary to initiate tumorigenesis in normal cells is a central endeavour in cancer biology …

Increased tissue stiffness is a driver of breast cancer progression. The transcriptional
regulator YAP is considered a universal mechanotransducer, based largely on 2D culture …

Simple Summary Matrix stiffness is recognized as a critical factor in cancer progression.
Recent studies have shown that matrix stiffening is caused by the accumulation, contraction …

A growing body of evidence suggests that mechanical signals emanating from the cell's
microenvironment are fundamental regulators of cell behaviour. Moreover, at the …

In breast cancer, the increased stiffness of the extracellular matrix is a key driver of
malignancy. Yet little is known about the epigenomic changes that underlie the tumorigenic …

Epithelial–mesenchymal transition (EMT) mediated by fluid shear stress (FSS) in the tumor
microenvironment plays an important role in driving metastasis of the malignant tumor. As a …

Cross-talk between tumor cells and mechanical stress in the tumor microenvironment has
been shown to be involved in carcinogenesis. High mechanical stress in tumors can alter …

Mechanical tensions are usually generated during development at spatially defined regions
within tissues. Such physical cues dictate the cellular decisions of proliferation or cell cycle …

Mechanotransduction is the ability of a cell to sense mechanical cues from its
microenvironment and convert them into biochemical signals to elicit adaptive transcriptional …