An epigenetic rheostat of experience: DNA methylation of OXTR as a mechanism of early life allostasis

JS Danoff, JJ Connelly, JP Morris… - Comprehensive …, 2021 - Elsevier
Oxytocin is a neuropeptide hormone which is involved in regulation of social behavior,
stress response, muscle contraction, and metabolism. Oxytocin signaling is dependent on its …

[HTML][HTML] Epigenetic variability in the human oxytocin receptor (OXTR) gene: A possible pathway from early life experiences to psychopathologies

EJ Kraaijenvanger, Y He, H Spencer, AK Smith… - Neuroscience & …, 2019 - Elsevier
The human oxytocin (OXT) system is implicated in the regulation of complex social
behaviors, as well as in psychopathologies characterized by social deficits. Emerging …

Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression

JS Danoff, KL Wroblewski, AJ Graves, GC Quinn… - Clinical …, 2021 - Springer
Background The neuropeptide oxytocin regulates mammalian social behavior. Disruptions
in oxytocin signaling are a feature of many psychopathologies. One commonly studied …

Epigenetic regulation of the oxytocin receptor gene: implications for behavioral neuroscience

R Kumsta, E Hummel, FS Chen… - Frontiers in …, 2013 - frontiersin.org
Genetic approaches have improved our understanding of the neurobiological basis of social
behavior and cognition. For instance, common polymorphisms of genes involved in oxytocin …

DNA methylation of OXTR is associated with parasympathetic nervous system activity and amygdala morphology

K Lancaster, L Goldbeck, MH Puglia… - Social cognitive and …, 2018 - academic.oup.com
Oxytocin has anxiolytic properties whose mechanisms of action are still being identified.
DNA methylation in the promoter region of the oxytocin receptor gene (OXTR), an epigenetic …

Brain region-specific methylation in the promoter of the murine oxytocin receptor gene is involved in its expression regulation

H Harony-Nicolas, S Mamrut, L Brodsky… - …, 2014 - Elsevier
Oxytocin is a nine amino acid neuropeptide that is known to play a critical role in fetal
expulsion and breast-feeding, and has been recently implicated in mammalian social …

The role of oxytocin receptor gene (OXTR) DNA methylation (DNAm) in human social and emotional functioning: a systematic narrative review

C Maud, J Ryan, JE McIntosh, CA Olsson - BMC psychiatry, 2018 - Springer
Abstract Background The neuropeptide Oxytocin (OXT) plays a central role in birthing,
mother-infant bonding and a broad range of related social behaviours in mammals. More …

Oxytocin, stress and social behavior: neurogenetics of the human oxytocin system

R Kumsta, M Heinrichs - Current opinion in neurobiology, 2013 - Elsevier
The neuropeptide oxytocin has had key roles throughout mammalian evolution in the
regulation of complex social cognition and behaviors, such as attachment, parental care …

Epigenetic modification of the oxytocin receptor gene influences the perception of anger and fear in the human brain

MH Puglia, TS Lillard, JP Morris… - Proceedings of the …, 2015 - National Acad Sciences
In humans, the neuropeptide oxytocin plays a critical role in social and emotional behavior.
The actions of this molecule are dependent on a protein that acts as its receptor, which is …

Oxytocin receptor expression patterns in the human brain across development

J Rokicki, T Kaufmann, AMG De Lange… - …, 2022 - nature.com
Oxytocin plays a vital role in social behavior and homeostatic processes, with animal models
indicating that oxytocin receptor (OXTR) expression patterns in the brain influence behavior …