Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.
M Matsukura, K Shinozuka, G Zon… - Proceedings of the …, 1987 - National Acad Sciences
Nuclease-resistant phosphorothioate analogs of certain oligodeoxynucleotides have been
tested in vitro as antiviral agents against human immunodeficiency virus (HIV) in human T …
tested in vitro as antiviral agents against human immunodeficiency virus (HIV) in human T …
Oligodeoxynucleoside phosphoramidates and phosphorothioates as inhibitors of human immunodeficiency virus.
S Agrawal, J Goodchild, MP Civeira… - Proceedings of the …, 1988 - National Acad Sciences
Modified oligodeoxynucleotides complementary to RNA of human immunodeficiency virus 1
(HIV-1) were tested for their ability to inhibit virally induced syncytium formation and …
(HIV-1) were tested for their ability to inhibit virally induced syncytium formation and …
Cholesteryl-conjugated oligonucleotides: synthesis, properties, and activity as inhibitors of replication of human immunodeficiency virus in cell culture.
RL Letsinger, GR Zhang, DK Sun… - Proceedings of the …, 1989 - National Acad Sciences
A family of oligonucleotides and phosphorothioate oligonucleotide analogues was
synthesized with a cholesteryl group tethered at the 3'-terminal internucleoside link. This …
synthesized with a cholesteryl group tethered at the 3'-terminal internucleoside link. This …
Inhibition of human immunodeficiency virus in early infected and chronically infected cells by antisense oligodeoxynucleotides and their phosphorothioate analogues.
S Agrawal, T Ikeuchi, D Sun, PS Sarin… - Proceedings of the …, 1989 - National Acad Sciences
Antisense oligodeoxynucleotides, both the phosphorothioate analogues and unmodified
oligomers of the same sequence, inhibit replication and expression of human …
oligomers of the same sequence, inhibit replication and expression of human …
Mode of action of 5'-linked cholesteryl phosphorothioate oligodeoxynucleotides in inhibiting syncytia formation and infection by HIV-1 and HIV-2 in vitro
CA Stein, R Pal, AL DeVico, G Hoke, S Mumbauer… - Biochemistry, 1991 - ACS Publications
Revised Manuscript Received November 13, 1990 abstract: A phosphorothioate
homocytidine 10-mer containing a cholesteryl moiety covalently linked to the 5'-end (Chol …
homocytidine 10-mer containing a cholesteryl moiety covalently linked to the 5'-end (Chol …
Long-term treatment of human immunodeficiency virus-infected cells with antisense oligonucleotide phosphorothioates.
J Lisziewicz, D Sun, V Metelev… - Proceedings of the …, 1993 - National Acad Sciences
The antiviral activity of antisense oligodeoxynucleotide phosphorothioates complementary
to the tat gene, the gag mRNA, and the rev mRNA were studied in a long-term infection …
to the tat gene, the gag mRNA, and the rev mRNA were studied in a long-term infection …
Inhibition of acquired immunodeficiency syndrome virus by oligodeoxynucleoside methylphosphonates.
PS Sarin, S Agrawal, MP Civeira… - Proceedings of the …, 1988 - National Acad Sciences
Antisense oligodeoxynucleotides containing internucleoside methylphosphonate linkages
were examined for their ability to inhibit human immunodeficiency virus (HIV)-induced …
were examined for their ability to inhibit human immunodeficiency virus (HIV)-induced …
GEM* 91—an antisense oligonucleotide phosphorothioate as a therapeutic agent for AIDS
S Agrawal, JINYAN TANG - Antisense research and development, 1992 - liebertpub.com
THErationale for AIDS chemotherapy with GEM 91 is based on the use of antisense
oligonucleotides to specifically inhibit the expression of human immunodeficiency virus (HIV …
oligonucleotides to specifically inhibit the expression of human immunodeficiency virus (HIV …
Phosphorothioate oligodeoxycytidine interferes with binding of HIV-1 gp120 to CD4
CA Stein, LM Neckers, BC Nair… - JAIDS Journal of …, 1991 - journals.lww.com
In addition to their properties as sequence-specific inhibitors of gene expression, sequence
nonspecific phosphorothioate oligodeoxynucleotides have been shown to protect against …
nonspecific phosphorothioate oligodeoxynucleotides have been shown to protect against …
Phosphoroselenoate oligodeoxynucleotides: synthesis, physico-chemical characterization, anti-sense inhibitory properties and anti-HIV activity
K Mori, C Boiziau, C Cazenave… - Nucleic acids …, 1989 - academic.oup.com
Oligodeoxynucleotides with a phosphorus atom in which one of the non-bridging oxygen
atoms is substituted by selenium were prepared and investigated with respect to their …
atoms is substituted by selenium were prepared and investigated with respect to their …