Strong linkage disequilibrium (LD) was found between DNA marker XV2c and the cystic
fibrosis (CF) locus (delta= 0.46) and between DNA marker KM19 and CF (delta= 0.67) in …

The linkage of polymorphic DNA markers on chromosome 7 to cystic fibrosis (CF) was
examined in two pedigrees and a number of smaller nuclear families. The pedigrees are …

Linkage of cystic fibrosis (CF) to DNA and classical markers was studied in 36 families of two
or three generations with at least two living affected children. Among the 79 affected …

Although the gene responsible for cystic fibrosis (CF) has yet to be identified, a great deal
has already been learned about the mutations of this autosomal reces-sive disorder. The …

To determine the distribution and frequency of cystic fibrosis (CF) mutations in the Israeli
population, we have screened 96 patients for 11 relatively common mutations. Five …

METHODS Period of Study The study comprised data on all legitimate live births in Hawaii
from January 1, 1950, through December 31, 1965. Racial Classification The complexity of …

To the Editor: The exciting recent discovery of the gene responsible for cystic fibrosis (CF)
and the molecular characterization of a common CF mutation (Kerem et al. 1989) have led …

The presence or absence of the major cystic fibrosis (CF) mutation, delta F508, in the
general patient population was determined by Kerem et al. using allele-specific …

The cystic fibrosis gene was recently cloned, and a three-base deletion removing
phenylalanine 508 from the coding region was identified as the mutation on the majority of …

A high incidence of cystic fibrosis (CF), 1/569 live births (0.00176), was found among 10 816
live births in an Ohio Amish isolate. The minimum gene frequency calculated from this …