Significant new information on the 1) 2 dopamine receptor has recently become available
from a combination of protein chemical and molecular genetic analyses. Molecular genetic …

Publisher Summary Receptors for the neurotransmitter dopamine have been studied
intensively over the past 30 years, and something of a consensus was reached in the late …

Proline is highly conserved in the presumed transmembrane a-helices of seven-
transmembrane helix-containing, G proteincoupled receptors. Unique properties of this …

Dopamine receptors belong to the seven transmembrane helix‐containing, G protein‐
coupled receptor superfamily. Mutagenesis studies suggest that dopamine and its …

The structural diversity of the human D2 dopamine receptor was examined at the nucleic
acid level. Sequence analysis of receptor cDNA clones isolated from human brain and …

Dopamine, a major neurotransmitter in the mammalian nervous system, exerts its
physiological effects through receptors of the G-protein-coupled receptor superfamily. Two …

Cloned human dopamine D2 receptor cDNA was isolated from a pituitary cDNA library and
found to encode an additional 29 amino acid residues in the predicted intracellular domain …

Publisher Summary The chapter discusses dopamine receptors that are divided into two
major subtypes referred to as D 1 and D 2. D 1 receptors activate the enzyme …

We have cloned a novel human intronless gene encoding a G-protein-coupled receptor of
the dopamine receptor family. Expression of this receptor in Cos-7 cells led to the high …

Dopamine receptors play an important role in neurotransmission within the central nervous
system, as evidenced by their affinity to and apparent site of action of a variety of …