Chronic administration of the neuroleptic drug haloperidol previously has been shown to
increase the density of striatal dopamine D 2 receptor, which is believed to be the underlying …

In the present study, quantitative in situ hybridization was used to analyse the effect of
haloperidol treatment on D 2 dopamine receptor gene expression in the rat caudate …

Chronic neuroleptic treatment induces an increase in the density of D2 dopamine receptors
in the striatum. The effect of prolonged administration of haloperidol on mRNA levels of the …

The regulation of the dopamine (DA) receptors is of considerable interest, in part because
treatment with antipsychotic drugs is known to upregulate striatal D2-like receptors. While …

Chronic treatment of rats with neuroleptics results in elevated numbers of dopamine D2-like
receptors. The present study was done to determine whether neuroleptics altered the …

Haloperidol is a widely prescribed antipsychotic that acts as a dopamine D2 receptor
antagonist. Chronic administration of haloperidol leads to an increase in striatal D2 receptor …

Chronic treatment (32 days) with sulpiride (100 mg/kg/day) up-regulated rat brain dopamine
D 3 receptor mRNA levels by 4-fold but had no effect on the mRNA levels encoding the …

Chronic treatment with haloperidol, a D 2-receptor antagonist and a neuroleptic, increases
the number of D 2-receptors in rat striatum. However, there have been inconsistent reports …

Fig. 1. Effects of chronic haloperidol treatment (n= 4) or of unilateral 6-hydroxydopamine (6-
OHDA) lesions of nigrostriatal dopamine neurons (n= 7) on dopamine D 2 mRNA levels (a) …

We used oligonucleotide probes to isolate cDNAs that encode two subtypes of D2 dopamine
receptors (“D2 long” and “D2 short”). In situ hybridization histochemistry with cRNA probes …