A human PET study was performed with carbon-11 labelled melatonin in a healthy
volunteer. Plasma pharmacokinetics of melatonin and 6-sulfatoxymelatonin were …

Melatonin, a hormone of the pineal gland, has been labelled with the positron-emitting
radionuclide, carbon-11 (t 1 2= 20.4 min), for study in vivo by positron emission tomography …

The distribution of 14C‐Melatonin (14C‐MT) after systemic injection was studied in the
plasma, cerebrospinal fluid (CSF), and brain of rats. Chromatographic analysis (thin‐layer …

The distribution of [14 C] melatonin ([14 C] MT) after systemic injection was studied in the
plasma and brain of golden hamsters. Thin-layer chromatographic analysis indicated that …

A specific, sensitive and reproducible high-performance liquid chromatographic (HPLC)
method is described for the simultaneous measurement of 6-hydroxymelatonin and …

In humans, the pineal gland or epiphysis represents the evolutive term of an organ which
has been submitted to profound modifications during evolution. Indeed, although it is an …

Melatonin has recently garnered interest as a possible treatment for sleep disorders, and
this has created a desire for appropriate pharmacokinetic studies. No method has yet been …

The fate of 3H‐melatonin after its intracerebroventricular administration was studied both in
different brain regions and in subcellular fractions. The rate of disappearance of 3H …

A validated new and precise reversed‐phase high‐performance liquid chromatographic
method for the determination of melatonin in human plasma and cerebrospinal fluid, with 5 …

Yeleswaram K, McLaughlin LG, Knipe JO, Schabdach D. Pharmacokinetics and oral
bioavailability of exogenous melatonin in preclinical animal models and clinical implications …