The high prevalence of hypercoagulative states in cancer patients has been known for more
than a century. Venous thrombosis in gastric cancer was described by Trousseau in 1865 …

In 1878, Billroth discovered that tumor cells invest themselves in a fibrin thrombus, and he
hypothesized that fibrin promotes tumor growth and invasion. Since then, many observations …

Although Trousseau1 was the earliest observer who noted the association between cancer
and thrombosis, it was Billroth2 who first described the presence of tumor cells within a …

Haemostasis is a system of finely adjusted interactions between cells, enzymatic reaction
cascades and inhibitors. Disturbances of this balance occur in many disorders, especially in …

Abnormal hemostasis is a fundamental property of malignant disease, not merely an
epiphenomenon attributable to therapy or to chronic illness. Many types of tumor cells …

Critical information on the nature of the coagulation-cancer interaction has been obtained
from a number of sources. In vitro/ex vivo sources of information include assays performed …

Development of cancer is associated with activation of blood coagulation. The results of
laboratory tests clearly demonstrate that fibrin formation and dissolution is continuously …

An array of fibrinolysis tests was applied to the plasmas of 125 untreated patients with breast
carcinoma and malignant melanoma, localized or spread to regional lymph nodes with no …

It has been known for over a century that blood coagulation and fibrinolysis pathways are
activated systemically in patients with malignancy. Recent studies have revealed evidence …

A volume of data that has accumulated for over a century has suggested that fibrin may
facilitate the persistence and progression of malignancy. Techniques that have been …