We established an efficient and nontoxic in vivo gene transfer method mediated by the
Sendai virus (hemagglutinating virus of Japan [HVJ]), liposomes, and nuclear protein. In this …

Transgenic mice containing the human renin gene were constructed with the aim of
examining the tissue-and cell-specific expression of human renin. The human renin …

We developed a model of spontaneously high human renin hypertension in the rat by
producing two transgenic strains, one for human angiotensinogen with the endogenous …

Transgenic mice are being used as an assay to identify the DNA sequences that direct the
tissue specificity and physiological regulation of murine renin gene expression. In initial …

A carboxy terminal renin complementary DNA (cDNA) clone from rat kidney was isolated,
characterized, and used as a probe for renin messenger RNA (mRNA) quantification in …

We examined the effect of chronic human renin infusion and human renin inhibition on
blood pressure in a unique transgenic rat model. We infused incremental doses of human …

To delineate tissue sites of renin synthesis the levels of renin enzyme activity and renin
mRNA sequence were measured in various organs of adult male outbred Swiss mice. Blots …

We have generated a transgenic model consisting of both the human renin and human
angiotensinogen genes to study further the role played by the renin-angiotensin system in …

Transgenic mice carrying human renin gene were produced by microinjection of 15
kilobases (kb) DNA molecules with up to 3 kb of 5′-flanking sequence and 1.2 kb of 3 …

To study the effect of antihypertensive therapy on the regulation of renin gene expression,
the levels of tissue renin messenger RNA (mRNA) were measured after treatment with a …