Evaluation of sustained-release granules of chlorphenesin carbamate in dogs and humans

A Masayuki, F Atsushi, M Tohru, Y Kenji… - International journal of …, 1993 - Elsevier
The bioavailability and pharmacokinetic properties of two sustained-release (SR)
formulations of chlorphenesin carbamate (CPC) with different in vitro release rates were …

Release and absorption characteristics of chlorphenesin carbamate sustained-release formulations: In vitro-in vivo and in vivo dog-human correlations

M Akimoto, A Furuya, M Nakamura, T Maki… - International journal of …, 1995 - Elsevier
The bioavailability of chlorphenesin carbamate (CPC) in sustained-release (SR)
formulations exhibiting different in vitro release characteristics in dogs and humans was …

Preparation of codeine-resinate and chlorpheniramine-resinate sustained-release suspension and its pharmacokinetic evaluation in beagle dogs

HX Zeng, G Cheng, WS Pan, GP Zhong… - Drug development and …, 2007 - Taylor & Francis
Using ion exchange resins (IERs) as carriers, a dual-drug sustained release suspension
containing codeine, and chlorpheniramine had been prepared to elevate drug safety …

Bioavailability of regular and controlled-release chlorpheniramine products

JA Kotzan, JJ Vallner, JT Stewart, WJ Brown… - Journal of …, 1982 - Elsevier
The bioavailability of chlorpheniramine regular-release versus controlled-release products
was compared using 15 human subjects. The dosage forms evaluated were an 8-mg barrier …

Bioequivalence and pharmacokinetics of chlorpheneramine in healthy human volunteers.

TA Najjar, OA Al-Alsheikh, AA Al-Dhawailie… - International journal of …, 1995 - europepmc.org
This study was carried out to evaluate the bioavailability of a new regular release tablet
formulation of chlorphenamine (CPA)(Histop) relative to a reference formula (Piriton) using …

In vitro and in vivo correlation for controlled-release formulation of d-chlorpheniramine maleate

N KATORI, K OKUDAIRA, N AOYAGI… - Journal of …, 1991 - jstage.jst.go.jp
Four commercial controlled-release tablets of d—chlorpheniramine maleate, which showed
various drug release properties, were administered to beagle dogs, and the correlation …

Correlation of in Vitro Release Rate and in Vivo Absorption Characteristics of Four Chlorpheniramine Maleate Extended-Release Formulations

P Mojaverian, E Radwanski, CC Lin, P Cho… - Pharmaceutical …, 1992 - Springer
An in vitro/in vivo correlation was established for four formulations of chlorpheniramine
maleate (histamine, H 1-blocker) extended-release tablets exhibiting different in vitro …

In vitro/in vivo evaluation of a liquid sustained release dosage form of chlorpheniramine

OL Sprockel, JC Price, R Jennings… - Drug Development …, 1989 - Taylor & Francis
Chlorpheniramine-resin complexes were coated with cellulose acetate butyrate to yield
microcapsules with a geometric mean diameter of 346 μm. In vitro release rate of …

HPLC Assay for Basic Amine Drug in Plasma Using a Silica Gel Column and an Aqueous Mobile Phase–Application in a Pilot Bioavailability Study of …

LH Pao, OYP Hu - Drug development and industrial pharmacy, 1994 - Taylor & Francis
A high performance liquid chromatographic (HPLC) method that involves the use of a silica
gel column and an aqueous mobile phase for simultaneous separation of chlorpheniramine …

Comparative pharmacokinetics of chlorphenesin carbamate and methocarbamol in man

AA Forist, RW Judy - Journal of Pharmaceutical Sciences, 1971 - Elsevier
Serum drug levels following oral administration of large single doses of chlorphenesin
carbamate and methocarbamol were fitted to a one-compartment open model. The …