Abstract The GABA $\sb {\rm A} $ receptor complex is a hetero-oligomeric complex that
includes an intrinsic chloride channel and multiple allosteric modulatory sites for the …

Recent findings suggest that steroids with sedative-hypnotic properties interact specifically
with the γ-aminobutyric acid A/benzodiazepine receptor-chloride ionophore complex …

Naturally occurring 3-α-hydroxy ring A-reduced metabolites of progesterone and
deoxycorticosterone and their synthetic analogues bind to specific sites within the …

The functioning of the GABA A receptor-chloride ion channel is subject to several
modulatory influences. Facilitation by benzodiazepines and barbiturates and antagonism by …

This review describes the modulation of the GABAa receptor by steroid hormones and
barbiturates and proposes guidelines for further research. Having examined the complex …

Neuroactive steroids are a new class of steroids that do not interact with any of the classical
cytosolic hormonal steroid receptors. The most well-documented examples are those that …

Neuroactive steroids and other positive modulators of GABA A receptors showed regional
variation in both the efficacy and potency for modulation of [35 S] TBPS binding to rat brain …

Certain endogenous steroids are modulators of GABAA receptors. Tetrahydroprogesterone
(THP, 5α‐pregnan‐3α‐ol‐20‐one) and tetrahydrodeoxy‐corticosterone (THDOC, 5α …

In 1984, Harrison and Simmonds demonstrated the synthetic steroidal anaesthetic
alphaxalone (5 a-pregnan-3a-ol-ll, 20-dione) to enhance potently and selectively the …

Allosteric modulation by neuroactive steroids of radioligand binding sites on the GABAA
receptor complex was demonstrated by autoradiography in vitro in several regions of human …