We have used apolipoprotein genes to investigate the signal transduction mechanisms
involved in the control of intestinal specific gene expression. The human apoAI, apoCIII, and …

The gene coding for apolipoprotein AI (apoAI), a plasma protein involved in the transport of
cholesterol and other lipids in the plasma, is expressed predominantly in liver and intestine …

Studies using transgenic mice indicate that expression of the human apolipoprotein (apo) AI
gene in the liver and small intestine is controlled by spatially distinct cis-acting DNA …

To understand the factors contributing to the synthesis of human apolipoprotein AI (apoAI),
relative apoAI synthesis was measured from endoscopic biopsy samples obtained from 18 …

We have isolated and characterized a 2.5-kilobase pairs genomic DNA fragment which
includes the 5′-flanking region and the first and second exons of the human apolipoprotein …

We have generated transgenic mice carrying wild-type promoters of the human
apolipoprotein AI (apoA-I)-apoCIII gene cluster or promoters mutated in their hormone …

In mammals, the gene coding for apolipoprotein AI (apoAI), a protein of the plasma lipid
transport system, is expressed only in the liver and the intestine. A series of plasmids …

In the small intestine, the expression of the apolipoprotein (apo) C-III and A-IV genes is
restricted to the enterocytes of the villi. We have previously shown that, in transgenic mice …

We have generated transgenic mice carrying wild-type and mutant forms of the
apolipoprotein (apo) AI/apoCIII gene cluster. Mutations were introduced either in one or in …

Using recombinant adenoviral vectors and a dominant negative mutant of HNF-4, we have
examined the contribution of hepatocyte nuclear factor 4 (HNF-4) to endogenous …