Vitamin A contained in the lipid droplets of rat liver stellate cells is substrate for acid retinyl ester hydrolase

V Azaïs-Braesco, I Dodeman, S Delpal… - … et Biophysica Acta (BBA …, 1995 - Elsevier
Vitamin A is stored in the lipid droplets of liver stellate cells (LSCs), as retinyl esters whose
hydrolysis is necessary for the secretion of retinol into the blood. Here, we isolated these …

Expression of carboxylesterase and lipase genes in rat liver cell-types

T Mello, A Nakatsuka, S Fears, W Davis… - Biochemical and …, 2008 - Elsevier
Approximately 80% of the body vitamin A is stored in liver stellate cells with in the lipid
droplets as retinyl esters. In low vitamin A status or after liver injury, stellate cells are …

[HTML][HTML] Lysosomal acid lipase is the major acid retinyl ester hydrolase in cultured human hepatic stellate cells but not essential for retinyl ester degradation

C Wagner, V Hois, L Pajed, LM Pusch… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Vitamin A is stored as retinyl esters (REs) in lipid droplets of hepatic stellate cells (HSCs). To
date, two different pathways are known to facilitate the breakdown of REs:(i) Hydrolysis of …

Hepatic retinol metabolism: role of the various cell types.

R Blomhoff - 1987 - cabidigitallibrary.org
A review of recent studies details the involvement of parenchymal and stellate cells in
hepatic retinol metabolism. Parenchymal cells take up newly absorbed retinyl esters in …

Characterization of liver stellate cell retinyl ester storage

G Trøen, A Nilsson, KR Norum… - Biochemical …, 1994 - portlandpress.com
The stellate cells of the liver are the main storage site of retinyl esters in the body. During
cultivation in vitro of stellate cells isolated from rat and rabbit livers were observed that the …

Regulation of vitamin A transport into cultured stellate cells of rat liver: studies by anchored cell analysis and sorting system

T Matsuura, S Nagamori, S Hasumura, H Sujino… - Experimental cell …, 1993 - Elsevier
Stellate cells (SC) in the liver store the most retinoid in the body, but the mechanisms of
specific retinoid transport into SC remain to be elucidated. In this study, to analyze the …

Retinol Esterification Activity Contributers to Retinol Transport in Stellate Cells

T Matsuura, S Hasumura, K Nagamori - Cell structure and function, 1999 - jstage.jst.go.jp
抄録 The mechanisms of retinol transport and Accumulation in hepatic stellate cells (HSC)
remain to be clucidated. Our previous studies suggested that retinol esterfication activity …

Hydrolysis of retinyl esters by non-specific carboxylesterases from rat liver endoplasmic reticulum

R Mentlein, E Heymann - Biochemical Journal, 1987 - portlandpress.com
The four most important non-specific carboxylesterases from rat liver were assayed for their
ability to hydrolyse retinyl esters. Only the esterases with pI 6.2 and 6.4 (= esterase ES-4) …

Storage of vitamin A in extrahepatic stellate cells in normal rats

NE Nagy, KB Holven, N Roos, H Senoo, N Kojima… - Journal of lipid …, 1997 - Elsevier
In mammals, vitamin A is primarily stored as retinyl esters in hepatic stellate cells under
normal dietary intake of the vitamin. Previously, extrahepatic vitamin A-storing stellate cells …

Hydrolysis of retinyl palmitate by enzymes of rat pancreas and liver: differentiation of bile salt-dependent and bile salt-independent, neutral retinyl ester hydrolases in …

EH Harrison, MZ Gad - Journal of Biological Chemistry, 1989 - ASBMB
Previous studies have demonstrated that homogenates of the livers of rats contain a neutral
retinyl ester hydrolase activity that requires millimolar concentrations of bile salts for maximal …